| 934390-67-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 934390-67-7
• 化学式: C₂₈H₃₈N₂O₁₀
• 分子量: 562.617
• InChiKey: APIWCORSFRZNCL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以75%的产率得到
  参考文献：
  名称：

  A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity

  摘要：

  Fast and convenient methods are required for the detection of novel catalysts. We have developed a new assay to allow direct visualization of retro-aldol retro-Michael catalytic activity and have demonstrated it with catalytic antibody 38C2. The assay is based on a catalytic cleavage of a physiologically stable substrate to release 3,4-cyclohexeneoesculetin. The latter then reacts with iron(III) to generate a non-soluble complex that precipitates in the form of a black dye. This assay may be used for screening new catalysts for retro-aldol retro-Michael activity with improved efficiency for specific prodrug activation.

  DOI：

  10.1016/j.bmcl.2006.12.057
• 作为产物：
  描述：

  2,3-dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one 在 potassium tert-butylate 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity

  摘要：

  Fast and convenient methods are required for the detection of novel catalysts. We have developed a new assay to allow direct visualization of retro-aldol retro-Michael catalytic activity and have demonstrated it with catalytic antibody 38C2. The assay is based on a catalytic cleavage of a physiologically stable substrate to release 3,4-cyclohexeneoesculetin. The latter then reacts with iron(III) to generate a non-soluble complex that precipitates in the form of a black dye. This assay may be used for screening new catalysts for retro-aldol retro-Michael activity with improved efficiency for specific prodrug activation.

  DOI：

  10.1016/j.bmcl.2006.12.057