N-[2-(2-thienyl)-4-thiazolyl]-N'-2-pyridinylurea | 400773-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[2-(2-thienyl)-4-thiazolyl]-N'-2-pyridinylurea
• 英文别名: 1-Pyridin-2-yl-3-(2-thiophen-2-yl-1,3-thiazol-4-yl)urea
• CAS: 400773-24-2
• 化学式: C₁₃H₁₀N₄OS₂
• 分子量: 302.381
• InChiKey: GTMSLIXSIKRFDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Urea compounds and methods of uses
  申请人：——

  公开号：US20020173507A1

  公开（公告）日：2002-11-21

  Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选择的新型尿素化合物对预防和治疗疾病有效，例如细胞增殖或凋亡介导的疾病。该发明涵盖了新型化合物、类似物、前药和其药用可接受的盐、预防和治疗涉及中风、癌症等疾病和其他疾病或病症的药物组合物和方法。该发明还涉及制备此类化合物的过程以及在此类过程中有用的中间体。
• Urea compounds as kinase inhibitors
  申请人：Amgen, Inc.

  公开号：EP1619184A2

  公开（公告）日：2006-01-25

  Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  精选的新型脲化合物可有效预防和治疗疾病，如细胞增殖或凋亡介导的疾病。本发明包括新型化合物、类似物、原药及其药学上可接受的盐、药物组合物以及用于预防和治疗涉及中风、癌症等疾病和其他弊病或病症的方法。本发明还涉及制造此类化合物的工艺以及在此类工艺中有用的中间体。
• UREA COMPOUNDS AND METHODS OF USES
  申请人：Amgen Inc.

  公开号：EP1309589A2

  公开（公告）日：2003-05-14
• US7196104B2
  申请人：——

  公开号：US7196104B2

  公开（公告）日：2007-03-27
• [EN] UREA COMPOUNDS AND METHODS OF USES<br/>[FR] COMPOSES D'UREE ET LEURS PROCEDES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2002014311A2

  公开（公告）日：2002-02-21

  Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.