1-(4-fluorobenzyl)-4-p-tolyl-5-(2-p-tolylethynyl)-1H-1,2,3-triazole | 1595281-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-fluorobenzyl)-4-p-tolyl-5-(2-p-tolylethynyl)-1H-1,2,3-triazole
• 英文别名: 1-[(4-Fluorophenyl)methyl]-4-(4-methylphenyl)-5-[2-(4-methylphenyl)ethynyl]triazole
• CAS: 1595281-84-7
• 化学式: C₂₅H₂₀FN₃
• 分子量: 381.452
• InChiKey: GYYAAWLKKBAMJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟氯苄 、 4-甲苯基乙炔 在 sodium azide 、 铜 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以80%的产率得到1-(4-fluorobenzyl)-4-p-tolyl-5-(2-p-tolylethynyl)-1H-1,2,3-triazole
  参考文献：
  名称：

  Nano-copper catalyzed three-component reaction to construct 1,4-substituted 1,2,3-triazoles

  摘要：

  Three-component reaction of alkyl halides, sodium azide with terminal alkynes can be catalyzed by nano-copper particles under ambient conditions. A series of 1,4-disubstituted-1,2,3-triazoles were obtained regioselectively by this one-pot strategy. Nano copper can be reused at least three times without significant deactivation. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.02.114

文献信息

• Cu(BTC)-MOF catalyzed multicomponent reaction to construct 1,4-disubstituted-1,2,3-triazoles
  作者：Xiangru Jia、Guangli Xu、Zhengyin Du、Ying Fu

  DOI：10.1016/j.poly.2018.05.058

  日期：2018.9

  Cu(BTC)-MOF catalyzed one-pot, three-component reaction of terminal alkynes, halides and sodium azide to form 1,4-disubstituted-1,2,3-triazoles was investigated. It was conducted in methanol under room temperature with good to excellent product yields. The Cu(BTC)-MOF catalyst could be easily recovered by filtration and be reused at least three recycles with no significant decrease in the yield. The method was demonstrated to be a truly green process with sustainability and economics. (C) 2018 Elsevier Ltd. All rights reserved.