2-(Oxolan-2-yloxy)ethyl prop-2-enoate | 158034-51-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Oxolan-2-yloxy)ethyl prop-2-enoate
• CAS: 158034-51-6
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: ZVHGQEABRRQBPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二氢呋喃 、 丙烯酸羟乙酯 在 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 以92%的产率得到2-(Oxolan-2-yloxy)ethyl prop-2-enoate
  参考文献：
  名称：

  Design of Asymmetric Particles Containing a Charged Interior and a Neutral Surface Charge: Comparative Study on in Vivo Circulation of Polyelectrolyte Microgels

  摘要：

  Lowering the modulus of hydrogel particles could enable them to bypass in vivo physical barriers that would otherwise filter particles with similar size but higher a modulus. Incorporation of electrolyte moieties into the polymer network of hydrogel particles to increase the swelling ratio is a straightforward and quite efficient way to decrease the modulus. In addition, charged groups in hydrogel particles can also help secure cargoes. However, the distribution of charged groups on the surface of a particle can accelerate the clearance of particles. Herein, we developed a method to synthesize highly swollen microgels of precise size with near-neutral surface charge while retaining interior charged groups. A strategy was employed to enable a particle to be highly cross-linked with very small mesh size, and subsequently PEGylated to quench the exterior amines only without affecting the internal amines. Acidic degradation of the cross-linker allows for swelling of the particles to microgels with a desired size and deformability. The microgels fabricated demonstrated extended circulation in vivo compared to their counterparts with a charged surface, and could potentially be utilized in in vivo applications including as oxygen carriers or nucleic acid scavengers.

  DOI：

  10.1021/ja503939n

文献信息

• GAS BARRIER FILM, RESIN BASE FOR ORGANIC ELECTROLUMINESCENT DEVICE, ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME, AND METHOD FOR PRODUCING GAS BARRIER FILM
  申请人：KONICA MINOLTA HOLDINGS, INC.

  公开号：EP2011639A1

  公开（公告）日：2009-01-07

  Disclosed is a gas barrier film which uses a polymerizable inorganic compound and has both high barrier property and high surface smoothness. Also disclosed are a resin base for organic electroluminescent devices using such a gas barrier film, an organic electroluminescent device and a method for producing a gas barrier film. The gas barrier film is characterized by comprising at least one ceramic film and a coating layer, which is formed through application of a coating liquid containing a polymerizable inorganic compound, on a resin film in this order. The gas barrier film is further characterized in that the ceramic film has a residual stress of not less than 0.01 MPa but not more than 20 MPa.

  本发明公开了一种气体阻隔膜，它使用了一种可聚合的无机化合物，同时具有高阻隔性和高表面平滑性。此外，还公开了使用这种气体阻隔膜的有机电致发光装置用树脂基、有机电致发光装置和气体阻隔膜的生产方法。该气体阻隔膜的特征在于，它由至少一层陶瓷膜和涂膜层组成，涂膜层是通过在树脂膜上涂抹含有可聚合无机化合物的涂膜液而依次形成的。该气体阻隔膜的进一步特征是，陶瓷膜的残余应力不小于 0.01 兆帕，但不大于 20 兆帕。
• Design of Asymmetric Particles Containing a Charged Interior and a Neutral Surface Charge: Comparative Study on <i>in Vivo</i> Circulation of Polyelectrolyte Microgels
  作者：Kai Chen、Jing Xu、J. Christopher Luft、Shaomin Tian、Jay S. Raval、Joseph M. DeSimone

  DOI：10.1021/ja503939n

  日期：2014.7.16

  Lowering the modulus of hydrogel particles could enable them to bypass in vivo physical barriers that would otherwise filter particles with similar size but higher a modulus. Incorporation of electrolyte moieties into the polymer network of hydrogel particles to increase the swelling ratio is a straightforward and quite efficient way to decrease the modulus. In addition, charged groups in hydrogel particles can also help secure cargoes. However, the distribution of charged groups on the surface of a particle can accelerate the clearance of particles. Herein, we developed a method to synthesize highly swollen microgels of precise size with near-neutral surface charge while retaining interior charged groups. A strategy was employed to enable a particle to be highly cross-linked with very small mesh size, and subsequently PEGylated to quench the exterior amines only without affecting the internal amines. Acidic degradation of the cross-linker allows for swelling of the particles to microgels with a desired size and deformability. The microgels fabricated demonstrated extended circulation in vivo compared to their counterparts with a charged surface, and could potentially be utilized in in vivo applications including as oxygen carriers or nucleic acid scavengers.