3-[3-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]propyl]-1-methyl-2,4-imidazolidinedione | 198064-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[3-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]propyl]-1-methyl-2,4-imidazolidinedione
• 英文别名: 3-[3-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]propyl]-1-methylhydantoin；3-[3-[4-(4-Chlorophenyl)-2-(2-methylimidazol-1-yl)-1,3-oxazol-5-yl]propyl]-1-methylimidazolidine-2,4-dione
• CAS: 198064-26-5
• 化学式: C₂₀H₂₀ClN₅O₃
• 分子量: 413.863
• InChiKey: MYEXUGQXZVJQRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲酰乙内脲 、 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]-1-propanol 以77%的产率得到3-[3-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]propyl]-1-methyl-2,4-imidazolidinedione
  参考文献：
  名称：

  Oxazole derivatives, their production and use

  摘要：

  一种新的化合物，其化学式如下：其中R1是卤素原子、可选择取代的杂环、羟基、硫醇或氨基团；A是可选择取代的酰基团、可选择取代的杂环基团、可选择取代的羟基团，或可选择酯化或酰胺化的羧基团；B是可选择取代的芳香基团；Y是二价脂肪烃基，或其盐，具有优秀的促进胰岛素分泌和降低血糖的作用，在糖尿病药物中有用。

  公开号：

  US06177452B1

文献信息

• Fused ring compound
  申请人：Tawaraishi Taisuke

  公开号：US20080194617A1

  公开（公告）日：2008-08-14

  The present invention provides an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. The present invention relates an agent for the prophylaxis or treatment of diabetes, which comprises a compound represented by wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof.

  本发明提供了一种用于预防或治疗糖尿病的药剂，具有优越的降血糖作用，并且与较少的副作用（如体重增加等）相关。本发明涉及一种用于预防或治疗糖尿病的药剂，包括由下式表示的化合物：其中每个符号如描述中所定义，或其盐或前药。
• Vdac regulator
  申请人：Sugiyama Yasuo

  公开号：US20050234116A1

  公开（公告）日：2005-10-20

  The present invention provides a VDAC regulator comprising a compound represented by the formula (I): wherein R 1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of Down's syndrome and the like, and the like.

  本发明提供了一种VDAC调节剂，其包含由式（I）表示的化合物：其中，R1是卤素原子、可选取代的杂环基、可选取代的羟基、可选取代的硫醇基或可选取代的氨基；A是可选取代的酰基、可选取代的杂环基、可选取代的羟基或可选酯化或酰胺化的羧基；B是可选取代的芳香基；X是氧原子、硫原子或可选取代的氮原子；Y是二价的烃基或杂环基、其盐或前药，该化合物有用作预防或治疗唐氏综合症等疾病的药物。
• Neurotrophin production/secretion promoting agent
  申请人：Momose Yu

  公开号：US20080269219A1

  公开（公告）日：2008-10-30

  A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R 1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.

  一种神经营养因子产生/分泌促进剂，包括式子如下的唑烷衍生物：其中，R1代表卤素原子、可能被取代的杂环基团、可能被取代的羟基、可能被取代的硫基或可能被取代的氨基；A代表可能被取代的酰基、可能被取代的杂环基团、可能被取代的羟基或可能被酯化或酰胺化的羧基；B代表可能被取代的芳香基团；X代表可能被取代的氧原子、硫原子或氮原子；Y代表双价烃基或杂环基团或其盐；该剂可用作预防或治疗神经病变的药剂。
• FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA
  申请人：Tawaraishi Taisuke

  公开号：US20110009384A1

  公开（公告）日：2011-01-13

  The present invention provides an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. The resent invention relates an agent for the prophylaxis or treatment of diabetes, which comprises a compound represented by wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof.

  本发明提供了一种用于预防或治疗糖尿病的药剂，具有优越的降血糖作用，且与体重增加等副作用较少相关。本发明涉及一种用于预防或治疗糖尿病的药剂，包括下式所示的化合物：其中每个符号如说明书中所定义，或其盐或前药。
• TGF-BETA SUPERFAMILY PRODUCTION/SECRETION PROMOTER
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1407770A1

  公开（公告）日：2004-04-14

  The present invention provides a TGF-β superfamily production/secretion promoter comprising a compound represented by the formula wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of dysautonomia, bladder dysfunction, hearing impairment, bone disease and the like.

  本发明提供了一种 TGF-β 超家族生产/分泌促进剂，它包括由式表示的化合物 其中 R1 是卤原子、任选取代的杂环基团、任选取代的羟基、任选取代的硫醇基团或任选取代的氨基； A 是任选取代的酰基、任选取代的杂环基团、任选取代的羟基或任选酯化或酰胺化的羧基；B 是任选取代的芳香基团；X 是氧原子、硫原子或任选取代的氮原子；Y 是二价烃基或杂环基团，或其盐或其原药，可用作预防或治疗自主神经功能障碍、膀胱功能障碍、听力障碍、骨病等的药物。