Methyl 4-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate | 1253226-21-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: Methyl 4-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• 英文别名: methyl 4-methyl-1,2,3,6-tetrahydropyridine-5-carboxylate
• CAS: 1253226-21-9
• 化学式: C₈H₁₃NO₂
• 分子量: 155.19
• InChiKey: NUYKQMDZFHPQTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF
  申请人：Harada Hironori

  公开号：US20120178735A1

  公开（公告）日：2012-07-12

  Provided is a 2H-chromene compound or a derivative thereof which has an excellent S1P1 agonist action. The 2H-chromene compound or derivative is particularly useful for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.

  提供了一种2H-色烯化合物或其衍生物，具有优异的S1P1激动剂作用。该2H-色烯化合物或衍生物特别适用于预防和/或治疗由不良淋巴细胞浸润引起的疾病或由细胞异常增殖或堆积引起的疾病。
• Process for the manufacture of isoquinoline diones
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0091565A1

  公开（公告）日：1983-10-19

  There is described a novel process for the maufacture of bicyclic diketones of the general formula wherein R' is lower alkyl or aryl-lower alkyl, starting from compounds of the general formulae wherein R' is as described above, one of R2 and R3 is methyl and the other is lower alkoxy and R4 is lower alkyl, and a novel process for the manufacture of compounds of formula II, wherein R2 is methyl, starting from 3- acetylpyridine. The compounds of formula I are useful as intermediates in the manufacture of 4,4a,5,6,7,8,8a,9- octahydro-4a,8a-trans-1H-pyrrolo[2,3-g)isoquinolin-4-ones having antipsychotic properties.

  本发明描述了一种从通式化合物（其中R'如上所述，R2和R3中的一个为甲基，另一个为低级烷氧基，R4为低级烷基）开始，制造通式为R'为低级烷基或芳基-低级烷基的双环二酮的新工艺，以及一种从3-乙酰基吡啶开始，制造通式II化合物（其中R2为甲基）的新工艺。 式I化合物可用作制造具有抗精神病特性的4,4a,5,6,7,8,8a,9-八氢-4a,8a-反式-1H-吡咯并[2,3-g]异喹啉-4-酮的中间体。
• 2H-CHROMENE DERIVATIVES AS STIMULATORS OF SPHINGOSINE 1-PHOSPHATE RECEPTOR
  申请人：Astellas Pharma Inc.

  公开号：EP2354134B1

  公开（公告）日：2016-02-24
• US8193378B2
  申请人：——

  公开号：US8193378B2

  公开（公告）日：2012-06-05
• [EN] ANTIOXIDANTS AND METHODS OF THEIR USE<br/>[FR] ANTIOXIDANTS ET LEURS PROCEDES D'UTILISATION
  申请人：UNIV MICHIGAN STATE

  公开号：WO2007117558A2

  公开（公告）日：2007-10-18

  [EN] The invention relates to compounds and compositions to treat some neurodegenerative diseases. In some embodiments, the invention relates to an antioxidant comprising a selenium atom and nitroxide group. In further embodiments, the antioxidant comprises peroxidase and superoxide dismutase activity. In some embodiments, the antioxidants are effective in treating neurodegenerative diseases including, but not limited to, Alzheimer's disease, Parkinson's disease, or multiple sclerosis. In additional embodiments, the invention relates to using compounds disclosed herein as free radical electromagnetic imaging agents.
  [FR] La présente invention concerne des composés et compositions traitant certaines maladies neurodégénératives. Dans certaines formes de réalisation, l'invention concerne un antioxydant comprenant un atome de sélénium et un groupe nitroxyde. Dans d'autres formes de réalisation, l'antioxydant présente une activité de péroxydase et de superoxyde dismutase. Dans certaines formes de réalisation, les antioxydants sont efficaces dans le traitement de maladies neurodégénératives comprenant, sans que cette liste soit exhaustive, la maladie d'Alzheimer, la maladie de Parkinson ou la sclérose en plaques. Dans d'autres formes de réalisation, l'invention a trait à l'utilisation de composés selon cette invention en tant qu'agents d'imagerie électromagnétique de radicaux libres.