N-(3-methoxypropyl)-4-methylaniline | 174197-46-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-methoxypropyl)-4-methylaniline
• CAS: 174197-46-7
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: WIFQIYIZBFYSDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲酚 、 3-甲氧基丙胺 在 [(η⁵-C₅(CH₃)₄^{3,5-bis(trifluoromethyl)benzene})RhCl₂]₂ 、 sodium carbonate 作用下， 以 正庚烷 为溶剂， 反应 36.0h， 以52%的产率得到N-(3-methoxypropyl)-4-methylaniline
  参考文献：
  名称：

  苯酚与胺的催化胺化

  摘要：

  鉴于酚类和胺类的广泛流行和易于获得，通过这些起始材料之间的直接偶联合成苯胺将极具吸引力。在这里，我们描述了一种铑催化的酚胺化，它提供了对各种苯胺的简洁访问，而水是唯一的副产物。亲惰性铑催化剂通过π-配位促进苯酚固有的困难的酮-烯醇互变异构化，允许随后与胺类脱水缩合。我们通过对具有各种电子特性的大量酚类和多种伯胺和仲胺进行反应，证明了这种氧化还原中性催化的普遍性。结构复杂的生物活性分子的后期功能化的几个例子，包括药物，

  DOI：

  10.1021/jacs.1c12622

文献信息

• Electrohydrogenation of Nitriles with Amines by Cobalt Catalysis
  作者：Tiantian Wang、Fangfang He、Wei Jiang、Jie Liu

  DOI：10.1002/anie.202316140

  日期：2024.2.12

  efficient electrocatalytic method for earth-abundant cobalt hydride generation through a sequence of cathodic reduction and protonation. The application of this molecular cobalt catalyst allows for electroreductive amination of nitriles to produce various secondary and tertiary amines, as well as deuterium isotope labeling applications from readily available deuterium source.

  本文报道了一种温和有效的电催化方法，通过一系列阴极还原和质子化来产生地球上丰富的氢化钴。这种分子钴催化剂的应用允许对腈进行电还原胺化以生产各种仲胺和叔胺，以及利用容易获得的氘源进行氘同位素标记应用。
• SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1150963A1

  公开（公告）日：2001-11-07
• NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES
  申请人：ENYO PHARMA

  公开号：US20210040059A1

  公开（公告）日：2021-02-11

  The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
• [EN] SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES SUBSTITUEES, PREPARATION ET UTILISATION DE CES DERNIERES, ET COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2000046214A1

  公开（公告）日：2000-08-10

  The present invention relates to compounds of formula (I) in which R?1, R2, and R3¿ have the meanings indicated in the claims, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of formula (I) have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use for the therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, and pharmaceutical compositions which comprise a compound of formula (I).
• [EN] NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES<br/>[FR] DÉRIVÉS DE THIOPHÈNE NON FUSIONNÉS ET LEURS UTILISATIONS
  申请人：ENYO PHARMA

  公开号：WO2019154956A1

  公开（公告）日：2019-08-15

  The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.