5-bromo-6-amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide | 661468-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-bromo-6-amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide
• 英文别名: 6-amino-5-bromo-3-morpholin-4-ylsulfonyl-1H-indole-2-carboxamide
• CAS: 661468-22-0
• 化学式: C₁₃H₁₅BrN₄O₄S
• 分子量: 403.256
• InChiKey: JRRCLXSUKXYBLM-UHFFFAOYSA-N

物化性质

• 沸点：
  699.6±65.0 °C(Predicted)
• 密度：
  1.788±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Combination therapy
  申请人：——

  公开号：US20040102360A1

  公开（公告）日：2004-05-27

  The present invention relates to methods of treating cancer using a combination of at least two Akt inhibitors or a compound which is an inhibitor of Akt and an inhibitor of a protein kinase, which methods comprise administering to a mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound(s) which are inhibitors of Akt and compound(s) which are inhibitors of protein kinases. The invention also relates to methods of preparing such compositions.

  本发明涉及使用至少两种Akt抑制剂的组合或一种同时是Akt抑制剂和蛋白激酶抑制剂的化合物来治疗癌症的方法，该方法包括向哺乳动物施用来自以下组合中选择的至少两种治疗剂的量，该组合包括Akt抑制剂和蛋白激酶抑制剂。该发明还涉及制备这种组合物的方法。
• Tyrosine kinase inhibitors
  申请人：Dinsmore J. Christopher

  公开号：US20050261496A1

  公开（公告）日：2005-11-24

  The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

  本发明涉及一种能够抑制、调节和/或调控受体型和非受体型酪氨酸激酶信号转导的化合物。本发明的化合物具有包含磺酰基吲哚基团的核心结构。本发明还涉及这些化合物的药学上可接受的盐、水合物和立体异构体。
• NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID
  申请人：Nihon Medi-Physics Co., Ltd.

  公开号：EP2213672A1

  公开（公告）日：2010-08-04

  A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1 is a group selected from the group consisting of a halogen substituent, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and hydroxyl group, R2 is a group selected from the group consisting of a cyano substituent, alkyl substituent with 1 to 4 carbon atoms and halogen substituent, is a group selected from the group consisting of a hydroxyl group, halogen substituent and substituent represented by the following formula: (wherein R4 is a hydrogen, halogen substituent or hydroxyl group, and m is an integer of 1 to 4), provided that a t least one of R1, R2, R3 and R4 represents a radioactive halogen, and a reagent comprising the same.

  本发明提供了一种可作为图像诊断淀粉样蛋白靶向探针的化合物，以及一种包含该化合物的试剂，用于检测沉积在生物组织上的淀粉样蛋白。提供了由下式（1）表示的化合物： 其中 R1 是选自由卤素取代基、1-4 个碳原子的烷基取代基、具有 1-4 个碳原子的烷基链的烷氧基取代基和羟基组成的基团，R2 是选自由氰基取代基、1-4 个碳原子的烷基取代基和卤素取代基组成的基团，是选自由羟基、卤素取代基和下式代表的取代基组成的基团： (其中 R4 是氢、卤素取代基或羟基，m 是 1 至 4 的整数），条件是 R1、R2、R3 和 R4 中至少有一个代表放射性卤素，以及由其组成的试剂。
• TYROSINE KINASE INHIBITORS
  申请人：Merck & Co., Inc.

  公开号：EP1534695A2

  公开（公告）日：2005-06-01
• EP1534695A4
  申请人：——

  公开号：EP1534695A4

  公开（公告）日：2008-06-11