2-nitro-L-tyrosine | 110012-34-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-nitro-L-tyrosine
• 英文别名: 2-Nitro-L-tyrosin；o-Nitrotyrosine；(2S)-2-amino-3-(4-hydroxy-2-nitrophenyl)propanoic acid
• CAS: 110012-34-5
• 化学式: C₉H₁₀N₂O₅
• 分子量: 226.189
• InChiKey: RCZUDMZUWULMID-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  L-酪氨酸 在 硝酸 作用下， 生成 3-硝基-L-酪氨酸 、 2-nitro-L-tyrosine
  参考文献：
  名称：

  Johnson; Kohmann, Journal of the American Chemical Society, 1915, vol. 37, p. 1870,1880

  摘要：

  DOI：

文献信息

• [EN] ARSENOPLATIN ANTI-CANCER AGENTS<br/>[FR] AGENTS ANTI-CANCÉREUX À BASE D'ARSÉNOPLATINE
  申请人：UNIV NORTHWESTERN

  公开号：WO2014028653A1

  公开（公告）日：2014-02-20

  Disclosed are compound having the structure of formula (I): wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C-R1 or C-R2; X is a Lewis base and Y1 and Y2 are independently oxygen- or sulfur-containing substituents, conjugates containing compounds of formula (I) and their use as chemotherapy agents.

  揭示了具有以下式（I）结构的化合物：其中M为Pt、Pd或Ni；Q为As、Sb或Bi；Z1为N；Z2为O或S；L1和L2分别独立为C（O）、C-R1或C-R2；X为路易斯碱，Y1和Y2分别独立为含氧或硫的取代基，所述共轭物包含式（I）化合物及其用作化疗药物。
• USES OF FORMULATIONS OF THYROID HORMONE ANALOGS AND NANOPARTICULATE FORMS THEREOF TO INCREASE CHEMOSENSIVITY AND RADIOSENSITIVITY IN TUMOR OR CANCER CELLS
  申请人：Davis Paul J.

  公开号：US20120315320A1

  公开（公告）日：2012-12-13

  Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof.

  本发明揭示了使用甲状腺激素类似物及其纳米粒子或聚合物形式，增加正常和/或化疗耐药肿瘤或癌细胞的化疗敏感性的方法。本发明还揭示了使用甲状腺激素类似物及其纳米粒子或聚合物形式，增加正常和/或放射线耐药肿瘤或癌细胞的放射线敏感性的方法。
• Molecules for targeting compounds to various selected organs or tissues
  申请人：Prosensa Technologies B.V.

  公开号：EP2505211A1

  公开（公告）日：2012-10-03

  The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.

  本发明提供了由器官、组织或肿瘤细胞归巢分子与分子连接而成的共轭物。例如，这种分子可以是寡核苷酸、小干扰 RNA、基因、病毒、蛋白质、药物或可检测剂。此外，本发明还提供了诊断或治疗肌肉或心脏病变的方法，即向患有或疑似患有病变的受试者施用一种分子或共轭物，该分子或共轭物与肌肉细胞或心脏细胞归巢、结合并被其吸收。
• Arsenoplatin anti-cancer agents
  申请人：Northwestern University

  公开号：US10118938B2

  公开（公告）日：2018-11-06

  Disclosed herein are methods of treating a cancer cell that include contacting a cancer cell with a compound having the structure of formula (I) M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C—R1 or C—R2; X is a Lewis base; Y1 and Y2 are independently selected from —OR3, —OR4, —SR3 and —SR4, wherein R1 and R2 are independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl; and R3 and R4 are independently selected from hydrogen, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl.

  本文公开了治疗癌细胞的方法，包括使癌细胞与具有式（I）结构的化合物接触 M为Pt、Pd或Ni；Q为As、Sb或Bi；Z1为N；Z2为O或S；L1和L2独立地为C(O)、C-R1或C-R2；X为路易斯碱；Y1 和 Y2 独立地选自-OR3、-OR4、-SR3 和-SR4，其中 R1 和 R2 独立地选自氢、卤素、氰基、酮、酯、醚、硫醇、硫醚、硫酯亚氨基、C1-C10 烷基、C1-C10 烯基、炔基、烷氧基、氨基、酰胺基、壬基、磺酰基、硫酰基、磷酰基、磷酰基酯、糖基、芳基、C3-C15 环烷基、杂芳基和 C3-C15 杂环烷基；R3 和 R4 独立选自氢、C1-C10 烷基、C1-C10 烯基、炔基、烷氧基、氨基、酰胺基、壬基、磺酰基、亚砜基、亚磺酰基、亚磷酸酯、糖基、芳基、C3-C15 环烷基、杂芳基和 C3-C15 杂环烷基。
• Optical contrast agents for optically modifying incident radiation
  申请人：——

  公开号：US20040258762A1

  公开（公告）日：2004-12-23

  A microparticle contains a cross-linked protein shell, and a surface coating.

  微粒子包含交联蛋白质外壳和表面涂层。