N-benzylidene-3,4-dihydro-3-(5-phenyl-1,2,4-oxadiazol-3-yl)-2H-chromen-2-amine | 1384471-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-benzylidene-3,4-dihydro-3-(5-phenyl-1,2,4-oxadiazol-3-yl)-2H-chromen-2-amine
• CAS: 1384471-85-5
• 化学式: C₂₄H₁₉N₃O₂
• 分子量: 381.434
• InChiKey: QAJIERHIHMNKPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60.51
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-amino-3,4-dihydro-2H-chromene-3-carbonitrile 在 盐酸羟胺 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 8.08h， 生成 N-benzylidene-3,4-dihydro-3-(5-phenyl-1,2,4-oxadiazol-3-yl)-2H-chromen-2-amine
  参考文献：
  名称：

  Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles

  摘要：

  In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N'-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium.

  DOI：

  10.1007/s00044-012-0103-1