5-甲基-2-[2-(1-甲基乙基)苯基]-N-[[4-(1H-1,2,3-三唑-1-基)苯基]甲基]-4-嘧啶胺 | 1572414-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-甲基-2-[2-(1-甲基乙基)苯基]-N-[[4-(1H-1,2,3-三唑-1-基)苯基]甲基]-4-嘧啶胺
• 中文别名: N-（4-（1H-1,2,3-三唑-1-基）苄基）-2-（2-异丙基苯基）-5-甲基嘧啶-4-胺
• 英文名称: ML323
• 英文别名: 5-methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
• CAS: 1572414-83-5
• 化学式: C₂₃H₂₄N₆
• 分子量: 384.5
• InChiKey: VUIRVWPJNKZOSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  29299090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

文献信息

• INHIBITORS OF THE USP1/UAF1 DEUBIQUITINASE COMPLEX AND USES THEREOF
  申请人：THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN

  公开号：US20150344443A1

  公开（公告）日：2015-12-03

  Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R 1 , R 2 , and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.

  本发明涉及抑制USP1/UAF1去泛素化酶复合物的抑制剂，例如式（I）中定义的R1、R2和Q，其对于治疗癌症和提高DNA损伤剂在癌症治疗中的疗效非常有用。本发明还涉及一种包含药学适用载体和本发明中至少一种化合物的组合物，一种在细胞中抑制异源二聚体去泛素化酶复合物的方法，以及一种增强正在接受抗癌药物治疗的哺乳动物的化疗治疗的方法。本发明还涉及一种制备本发明化合物的方法。
• Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US11136409B2

  公开（公告）日：2021-10-05

  The present invention is based, in part, on the identification of novel USP10 biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating AML.

  本发明部分基于新型 USP10 生物标记物和调节剂的鉴定及其使用方法，用于鉴定、评估、预防和治疗急性髓细胞白血病。
• COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS
  申请人：BUHRLAGE Sara

  公开号：US20190202929A1

  公开（公告）日：2019-07-04

  The present invention is based, in part, on the identification of novel USP10 biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating AML.
• METHODS OF TREATING CANCERS
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20210186964A1

  公开（公告）日：2021-06-24

  The disclosure relates to methods for treating cancers (e.g., cancers having a BRCA1 and/or BRCA2 mutation(s)) by administering to the subject an effective amount of a ubiquitin-specific protease 1 (USP1) inhibitor.
• US9802904B2
  申请人：——

  公开号：US9802904B2

  公开（公告）日：2017-10-31