2,3-Bis-(4-hydroxy-phenyl)-7-(tetrahydro-pyran-2-yloxy)-chroman-4-one | 871477-42-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2,3-Bis-(4-hydroxy-phenyl)-7-(tetrahydro-pyran-2-yloxy)-chroman-4-one
• CAS: 871477-42-8
• 化学式: C₂₆H₂₄O₆
• 分子量: 432.473
• InChiKey: PEXNWWRFGFPCBZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2,3-Bis-(4-hydroxy-phenyl)-7-(tetrahydro-pyran-2-yloxy)-chroman-4-one 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 7-Hydroxy-2,3-bis-(4-hydroxy-phenyl)-chroman-4-one
  参考文献：
  名称：

  Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

  摘要：

  A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.031
• 作为产物：
  描述：

  (E)-2,3-Bis-(4-hydroxy-phenyl)-1-[2-hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone 在 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 2,3-Bis-(4-hydroxy-phenyl)-7-(tetrahydro-pyran-2-yloxy)-chroman-4-one
  参考文献：
  名称：

  Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

  摘要：

  A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.031