ethyl 4-(N-benzyl-N-methylcarbamoyloxy)-2-butynoate | 90511-59-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 4-(N-benzyl-N-methylcarbamoyloxy)-2-butynoate
• 英文别名: ethyl 4-[benzyl(methyl)carbamoyl]oxybut-2-ynoate
• CAS: 90511-59-4
• 化学式: C₁₅H₁₇NO₄
• 分子量: 275.304
• InChiKey: MORAZPNVYGDYNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(N-benzyl-N-methylcarbamoyloxy)-2-butynoate 、 ammonium hydroxide 以36%的产率得到
  参考文献：
  名称：

  SUZUKI, KUNIO;USHIJIMA, RYOSUKE;MIYANO, TETSUJI;NAKAGAWA, SUSUMU, HETEROCYCLES, 29,(1989) N, C. 497-509

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 4-hydroxy-2-butynoate 、 N-甲基苄胺 以28%的产率得到
  参考文献：
  名称：

  SUZUKI, KUNIO;USHIJIMA, RYOSUKE;MIYANO, TETSUJI;NAKAGAWA, SUSUMU, HETEROCYCLES, 29,(1989) N, C. 497-509

  摘要：

  DOI：

文献信息

• Certain intermediate 3-carbamoyloxyalkyl propiolic acid derivatives
  申请人：Banyu Pharmaceutical Company, Ltd.

  公开号：US04914227A1

  公开（公告）日：1990-04-03

  A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##STR2## with a benzylidene compound represented by the general formula: ##STR3## (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: ##STR4## and a .beta.-keto-ester compound represented by the general formula: R.sup.4 --CO--CH.sub.2 --COOR.sup.2 (V) (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: ##STR5## with the benzylidene compound of the general formula III and ammonia or its salt; or (d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the .beta.-keto-ester compound of the general formula V and ammonia or its salt.

  一种制备2-氨基甲酰氧基烷基-1,4-二氢吡啶衍生物的方法，其通式为：##STR1## 包括以下步骤：(a)将通式为：##STR2## 的3-氨基-3-甲酰氧基烷基丙烯酸衍生物与通式为：##STR3## 的苯甲醛化合物反应；(b)将通式为II的3-氨基-3-甲酰氧基烷基丙烯酸衍生物与通式为IV的醛化合物和通式为R.sup.4 --CO--CH.sub.2 --COOR.sup.2(V)的β-酮酸酯化合物反应；(c)将通式为：##STR5## 的3-甲酰氧基烷基丙炔酸衍生物与通式为III的苯甲醛化合物和氨或其盐反应；或(d)将通式为VI的3-甲酰氧基烷基丙炔酸衍生物与通式为IV的醛化合物、通式为V的β-酮酸酯化合物和氨或其盐反应。
• Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives
  申请人：Banyu Pharmaceutical Company, Ltd.

  公开号：US04958024A1

  公开（公告）日：1990-09-18

  A process for preparing a 2-carbamoylocxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##STR2## with a benzylidene compound represented by the general formula: ##STR3## (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: ##STR4## and a .beta.-keto-ester compound represented by the general formula: R.sup.4 --CO--CH.sub.2 --COOR.sup.2 (V) (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: ##STR5## with the benzylidene compound of the general formula III and ammonia or its salt; or (d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the .beta.-keto-ester compound of the general formula V and ammonia or its salt.

  一种制备2-氨基甲氧基烷基-1,4-二氢吡啶衍生物的方法，其通式如下：##STR1## 包括：(a)将一种3-氨基-3-氨基甲氧基烷基丙烯酸衍生物与一种苯甲醛化合物反应，该苯甲醛化合物的通式为：##STR3## (b)将通式II的3-氨基-3-氨基甲氧基烷基丙烯酸衍生物与通式IV的醛化合物和通式R.sup.4--CO--CH.sub.2--COOR.sup.2(V)的β-酮酯化合物反应；(c)将一种3-氨基甲氧基烷基丙炔酸衍生物与通式III的苯甲醛化合物和氨或其盐反应；或(d)将通式VI的3-氨基甲氧基烷基丙炔酸衍生物与通式IV的醛化合物、通式V的β-酮酯化合物和氨或其盐反应。
• 3-amino-3-carbamoyloxyalkylacrylic acid intermediates to dihydropyridines
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US04739106A1

  公开（公告）日：1988-04-19

  A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##STR2## with a benzylidene compound represented by the general formula: ##STR3## (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: ##STR4## and a .beta.-keto-ester compound represented by the general formula: R.sup.4 --CO--CH.sub.2 --COOR.sup.2 (V) (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: ##STR5## with the benzylidene compound of the general formula III and ammonia or its salt; or (d) reacting the 3-carbamoyloyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the .beta.-keto-ester compound of the general formula V and ammonia or its salt.

  一种制备2-氨基甲酰氧基烷基-1,4-二氢吡啶衍生物的方法，该衍生物的化学式如下：##STR1## 包括以下步骤：(a)将一种化学式II所表示的3-氨基-3-甲酰氧基烷基丙烯酸衍生物与一种化学式III所表示的苯甲醛化合物反应；(b)将化学式II所表示的3-氨基-3-甲酰氧基烷基丙烯酸衍生物与一种化学式IV所表示的醛化合物以及一种化学式R.sup.4--CO--CH.sub.2--COOR.sup.2(V)所表示的β-酮酯化合物反应；(c)将一种化学式VI所表示的3-甲酰氧基烷基-丙炔酸衍生物与一种化学式III所表示的苯甲醛化合物以及氨或其盐反应；或者(d)将化学式VI所表示的3-甲酰氧基烷基-丙炔酸衍生物与化学式IV所表示的醛化合物、化学式V所表示的β-酮酯化合物以及氨或其盐反应。
• Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0101023A1

  公开（公告）日：1984-02-22

  A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: with a benzylidene compound represented by the general formula: (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde comoound reoresented bv the aeneral formula: and a β-keto-ester compound represented by the general formula: (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: with the benzylidene compound of the general formula III and ammonia or its salt: or (d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the β-keto-ester compound of the general formula V and ammonia or its salt, and the intermediates of formula II and VI.

  一种制备通式为 2-氨基甲酰氧基烷基-1,4-二氢吡啶衍生物的工艺： 其中包括 (a) 将通式为 3-氨基-3-氨基甲酰氧基烷基丙烯酸衍生物与通式为 与通式代表的亚苄基化合物反应： (b) 将通式 II 的 3-氨基-3-氨基甲酰氧基烷基丙烯酸衍生物与通式......代表的醛化合物和通式......代表的β-酮酯化合物反应： 和通式代表的 β-酮酯化合物反应： (c) 将通式代表的 3-氨基甲酰氧基烷基丙炔酸衍生物与通式代表的 β-酮酯化合物反应： 与通式 III 的亚苄基化合物和氨或其盐反应：或 (d) 将通式 VI 的 3-氨基甲酰氧基烷基丙炔酸衍生物与通式 IV 的醛化合物、通式 V 的 β-酮酯化合物和氨或其盐以及通式 II 和 VI 的中间产物反应。
• US4739106A
  申请人：——

  公开号：US4739106A

  公开（公告）日：1988-04-19