| 137506-35-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 137506-35-5
• 化学式: C₆₉H₈₀N₁₀O₁₂
• 分子量: 1241.45
• InChiKey: OEOFBIFEDTVFKZ-XRKMNDFKSA-N

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 二苯基磷酸 、 氢气 、 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 {4-[(2S,5S,8S,11S,14S,17R)-8-(4-Amino-butyl)-11-benzyl-14-(4-hydroxy-benzyl)-17-(1H-indol-3-ylmethyl)-5-isopropyl-10-methyl-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexaaza-cyclooctadec-2-yl]-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Synthesis of novel, highly potent cyclic-hexapeptide analogs of somatostatin. Potential application of orthogonal protection for affinity chromatography

  摘要：

  The syntheses of new cyclic hexapeptides are described. These peptides potently displace [I-125] CGP-23996 (des-Ala1, Gly2-desamino-Cys3[Tyr11]-dicarba3,14 SRIF) from SRIF receptors on AtT-20 cells. Two of these compounds are of potential value for the isolation of SRIF receptors by affinity chromatography. A key feature in the design was the use of orthogonal protection to provide selective covalent bonding to the solid support.

  DOI：

  10.1016/s0040-4039(00)92279-2