N4-ethyl-N2-[1-(4-methanesulfonylphenyl)-3-methyl-1H-pyrazol-4-yl]-5-trifluoromethylpyrimidine-2,4-diamine | 1374827-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N4-ethyl-N2-[1-(4-methanesulfonylphenyl)-3-methyl-1H-pyrazol-4-yl]-5-trifluoromethylpyrimidine-2,4-diamine
• 英文别名: 4-N-ethyl-2-N-[3-methyl-1-(4-methylsulfonylphenyl)pyrazol-4-yl]-5-(trifluoromethyl)pyrimidine-2,4-diamine
• CAS: 1374827-45-8
• 化学式: C₁₈H₁₉F₃N₆O₂S
• 分子量: 440.449
• InChiKey: OLFINRBYCWQNOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS<br/>[FR] DÉRIVÉS DE PYRAZOLE AMINOPYRIMIDINE EN TANT QUE MODULATEURS DU LRRK2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012062783A1

  公开（公告）日：2012-05-18

  Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

  化合物的结构式（I）或其药用盐，其中X，R1，R2，R3，R4和R5如本文所定义。还公开了制备这些化合物的方法，并将这些化合物用于治疗与LRRK2受体相关的疾病，如帕金森病。
• PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
  申请人：Baker-Glenn Charles

  公开号：US20120157427A1

  公开（公告）日：2012-06-21

  Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

  化合物I的公式为：或其药学上可接受的盐，其中X，R1，R2，R3，R4和R5如本文所定义。还公开了制备该化合物的方法以及使用该化合物治疗与LRRK2受体相关的疾病，如帕金森病的方法。
• Protease and inhibitor containing water-soluble films
  申请人：Novozymes A/S

  公开号：EP2799533A1

  公开（公告）日：2014-11-05

  The invention relates to enzyme and protease inhibitor containing water-soluble films, and their use in detergents.

  本发明涉及含有酶和蛋白酶抑制剂的水溶性薄膜及其在洗涤剂中的应用。
• DETERGENT COMPOSITIONS COMPRISING LIPASES
  申请人：The Procter & Gamble Company

  公开号：EP3461892A2

  公开（公告）日：2019-04-03

  Detergent compositions comprising a lipase variant of a parent lipase which has lipase activity and comprises one or more substitutions corresponding to G23S, D27N, A40, F51I,L, E56R, D57N, V60E,K, K98I, N101D, R118, G163S, T231R, N233R, Y220F, T244E, and P256T using SEQ ID NO: 2 for numbering. Water-soluble unit dose articles comprising water-soluble film and a detergent composition comprising lipase variants. Methods of cleaning and/or treatment of surfaces using such compositions.

  包含母体脂肪酶的脂肪酶变体的洗涤剂组合物，该变体具有脂肪酶活性，并包含一个或多个对应于G23S、D27N、A40、F51I,L、E56R、D57N、V60E,K、K98I、N101D、R118、G163S、T231R、N233R、Y220F、T244E和P256T的取代，使用SEQ ID NO:2进行编号。 水溶性单位剂量物品，包括水溶性薄膜和含有脂肪酶变体的洗涤剂组合物。使用这种组合物清洁和/或处理表面的方法。
• DETERGENT COMPOSITIONS COMPRISING POLYPEPTIDE VARIANTS
  申请人：The Procter & Gamble Company

  公开号：EP3476935A1

  公开（公告）日：2019-05-01

  Detergent compositions comprising polypeptide variants and methods of cleaning and/or treatment of surfaces using such compositions, and fabric treatment compositions comprising polypeptide variants. The compositions may comprise surfactants: anionic, nonionic and/or cationic.

  包含多肽变体的洗涤剂组合物和使用此类组合物清洁和/或处理表面的方法，以及包含多肽变体的织物处理组合物。这些组合物可包含阴离子、非离子和/或阳离子表面活性剂。