4-phenoxy-4'-(2-(dimethylamino)ethoxy)chalcone | 1389310-63-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-phenoxy-4'-(2-(dimethylamino)ethoxy)chalcone
• 英文别名: 4-Phenoxy-4'-dimethylaminoethoxychalcone；1-[4-[2-(dimethylamino)ethoxy]phenyl]-3-(4-phenoxyphenyl)prop-2-en-1-one
• CAS: 1389310-63-7
• 化学式: C₂₅H₂₅NO₃
• 分子量: 387.478
• InChiKey: OFCIHDDKDVHWGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-苯氧基苯甲醛 、 1-{4-[2-(二甲基氨基)乙氧基]苯基}乙酮 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 4-phenoxy-4'-(2-(dimethylamino)ethoxy)chalcone
  参考文献：
  名称：

  Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

  摘要：

  A library of 117 chalcones was screened for efflux pump inhibitory (EPI) activity against NorA mediated ethidium bromide efflux. Five of the chalcones (5-7, 9, and 10) were active and two chalcones (9 and 10) were equipotent to reserpine with IC50-values of 9.0 and 7.7 mu M, respectively. Twenty chalcones were subsequently proved to be inhibitors of the NorA efflux pump in everted membrane vesicles. Compounds 5, 7, and 9 synergistically increased the effect of ciprofloxacin on Staphylococcus aureus. Our results suggest that chalcones might be developed into drugs for overcoming multidrug resistance based on efflux transporters of microorganisms. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.05.025

文献信息

• ANTIBACTERIAL COMPOUNDS AND USES THEREOF
  申请人：The Children's Medical Center Corporation

  公开号：US20220023270A1

  公开（公告）日：2022-01-27

  Provided herein are compositions and methods for the treatment of infections resulting from antibiotic-resistant strains of bacteria.
• [EN] ANTIBACTERIAL COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ANTIBACTÉRIENS ET LEURS UTILISATIONS
  申请人：CHILDRENS MEDICAL CT CORP

  公开号：WO2020118036A1

  公开（公告）日：2020-06-11

  Provided herein are compositions and methods for the treatment of infections resulting from antibiotic-resistant strains of bacteria.