5-azepan-1-yl-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | 1100753-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-azepan-1-yl-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
• 英文别名: N-(2-adamantyl)-5-(azepan-1-yl)-1-phenylpyrazole-4-carboxamide
• CAS: 1100753-05-6
• 化学式: C₂₆H₃₄N₄O
• 分子量: 418.582
• InChiKey: ZOEOFBCJGHFZEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase
  申请人：Gillespie Paul

  公开号：US20090023709A1

  公开（公告）日：2009-01-22

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

  本文提供了式(I)的化合物，以及其药学上可接受的盐，其中取代基如规范中所披露。这些化合物及含有它们的药物组合物对于治疗疾病如二型糖尿病和代谢综合征等具有用处。
• INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2178845A2

  公开（公告）日：2010-04-28
• US7790711B2
  申请人：——

  公开号：US7790711B2

  公开（公告）日：2010-09-07
• [EN] INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE<br/>[FR] INHIBITEURS DE 11B-HYDROXYSTÉROÏDE DÉSHYDROGENASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009010416A2

  公开（公告）日：2009-01-22

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.