2-chloro-1-(2-methyl-5-nitro-1H-benzimidazol-1-yl)ethanone | 913706-24-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-chloro-1-(2-methyl-5-nitro-1H-benzimidazol-1-yl)ethanone
• 英文别名: 2-Chloro-1-(2-methyl-5-nitrobenzimidazol-1-yl)ethanone
• CAS: 913706-24-8
• 化学式: C₁₀H₈ClN₃O₃
• 分子量: 253.645
• InChiKey: QGRBZENFAMUFJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-chloro-1-(2-methyl-5-nitro-1H-benzimidazol-1-yl)ethanone 、 尿素 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以88%的产率得到4-(2-methyl-5-nitro-1H-benzimidazol-1-yl)-1H-imidazol-2(5H)-one
  参考文献：
  名称：

  Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

  摘要：

  Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 mu g] and 7 [IC50 = 8.29 mu g] were found to be active. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.033
• 作为产物：
  描述：

  2-甲基苯并咪唑 在 硫酸 、 硝酸 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.0h， 生成 2-chloro-1-(2-methyl-5-nitro-1H-benzimidazol-1-yl)ethanone
  参考文献：
  名称：

  Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

  摘要：

  Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 mu g] and 7 [IC50 = 8.29 mu g] were found to be active. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.033