N-[[(5S)-3-[3-fluoro-4-(2-carboxymethyl-2H-tetrazol-5-yl)-phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide | 1161795-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[[(5S)-3-[3-fluoro-4-(2-carboxymethyl-2H-tetrazol-5-yl)-phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide
• 英文别名: 2-[5-[4-[(5S)-5-(acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl]tetrazol-2-yl]acetic acid
• CAS: 1161795-38-5
• 化学式: C₁₅H₁₅FN₆O₅
• 分子量: 378.32
• InChiKey: AIZBLQPAAWFSPV-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• 1(2)H-tetrazol-5-yl-phenyl-oxazolidinones as antibacterial agents
  申请人：Ferrer Internacional, S.A.

  公开号：EP2072514A1

  公开（公告）日：2009-06-24

  The present invention provides a class of phenyl-oxazolidinones of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a radical of formula (i) or formula (ii): methods of preparing such compounds, pharmaceutical compositions comprising one or more of such compounds, and the use thereof in the manufacture of a medicament which is used in the treatment of bacterial infections.

  本发明提供了一类苯基噁唑烷酮化合物，其化学式为(I)：或其药用可接受的盐，其中：R1为化学式(i)或化学式(ii)的基团；制备这类化合物的方法；包含一种或多种这类化合物的药物组合物；以及将其用于制造用于治疗细菌感染的药物的用途。
• [EN] 1(2)H-TETRAZOL-5-YL-PHENYL-OXAZOLIDINONES AS ANTIBACTERIAL AGENTS<br/>[FR] 1(2)H-TÉTRAZOL-5-YL-PHÉNYL-OXAZOLIDINONES COMME AGENTS ANTIBACTÉRIENS
  申请人：FERRER INT

  公开号：WO2009077485A2

  公开（公告）日：2009-06-25

  The present invention provides a class of phenyl-oxazolidinones of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a radical of formula (i) or formula (ii): methods of preparing such compounds, pharmaceutical compositions comprising one or more of such compounds, and the use thereof in the manufacture of a medicament which is used in the treatment of bacterial infections.