1-(2-Thien-2-yl-2-oxo ethyl)-3[(3-phenyl)pyrazol-5-yl]-5-bromopyridinium chloride | 473882-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-Thien-2-yl-2-oxo ethyl)-3[(3-phenyl)pyrazol-5-yl]-5-bromopyridinium chloride
• 英文别名: 2-[3-bromo-5-(5-phenyl-1H-pyrazol-3-yl)pyridin-1-ium-1-yl]-1-thiophen-2-ylethanone;chloride
• CAS: 473882-38-1
• 化学式: C₂₀H₁₅BrN₃OS*Cl
• 分子量: 460.782
• InChiKey: VPWHHNLPTYQAQU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  77.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof
  申请人：TORRENT PHARMACEUTICALS LTD.

  公开号：US20030045554A1

  公开（公告）日：2003-03-06

  The invention discloses a new clause of a five membered heterocylic ring compounds of general formula 1 1 and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.

  本发明公开了一种新的通式11的五元杂环化合物及其药学或美容学可接受的盐，其中R1、R2、R3、R4、R5、A、B、X和Y在说明书中定义。本发明还公开了制备这些化合物及其治疗和美容应用的方法，特别是在管理与衰老相关和糖尿病血管并发症方面。所述化合物通过AGE（高级糖基化终产物）断裂剂、AGE抑制剂和自由基清除剂的三重作用发挥作用，使它们在不同的治疗和美容应用中最为适用。本发明还公开了包含这些化合物的药物和化妆品组合物以及治疗由体细胞中AGE和/或自由基积累引起的疾病的方法。
• HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP1373263B1

  公开（公告）日：2004-10-27
• US7223777B2
  申请人：——

  公开号：US7223777B2

  公开（公告）日：2007-05-29
• [EN] HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS<br/>[FR] COMPOSES HETEROCYCLIQUES POUR DES COMPLICATIONS VASCULAIRES DIABETIQUES ET LIEES AU VIEILLISSEMENT
  申请人：——

  公开号：WO2002085897A9

  公开（公告）日：2004-04-01

  [EN] The invention discloses a new clause of a five membered heterocyclic ring compounds of general formula (1) and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the managemnt of agin related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprisisng these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.
  [FR] La présente invention concerne une nouvelle disposition de composés à noyau de cinq chaînons répondant à la formule générale (I), dans laquelle : R1, R2, R3, R4, R5, A, B, X et Y sont tels que définis dans la description, ainsi que ses sels pharmaceutiquement et cosmétiquement acceptables. L'invention concerne également un procédé de préparation de ces composés et leurs applications thérapeutiques et cosmétiques notamment dans le traitement des complications vasculaires diabétiques et liées au vieillissement. Lesdits composés agissent par une triple action de décomposition de produits de glycation avancée, d'inhibition de produits de glycation avancée et de phagocyte de radicaux libres qui les rendent appropriés dans différentes applications thérapeutiques et cosmétiques. L'invention concerne en outre des compositions pharmaceutiques et cosmétiques comportant lesdits composés et un procédé de traitement de maladies causées par l'accumulation de produits de glycation avancée et/ou de radicaux libres dans les cellules somatiques.