5-Amino-1.1.3.3-tetrafluor-phthalan | 651-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 5-Amino-1.1.3.3-tetrafluor-phthalan
• 英文别名: 1,1,3,3-tetrafluoro-1,3-dihydro-isobenzofuran-5-ylamine；1,1,3,3-Tetrafluoro-2-benzofuran-5-amine
• CAS: 651-60-5
• 化学式: C₈H₅F₄NO
• 分子量: 207.127
• InChiKey: ISGUPLVYUDBZBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Bicyclic Amides as Kinase Inhibitors
  申请人：Bold Guido

  公开号：US20080287427A1

  公开（公告）日：2008-11-20

  The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising en a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
• Combinations Comprising a Vegf Receptor Inhibitor
  申请人：Billich Andreas

  公开号：US20080306058A1

  公开（公告）日：2008-12-11

  A composition comprising a VEGF receptor inhibitor and a penetration enhancer and uses thereof.
• BICYCLIC AMIDES AS KINASE INHIBITORS
  申请人：Bold Guido

  公开号：US20110301157A1

  公开（公告）日：2011-12-08

  The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
• Combinations Comprising a VEGF Receptor Inhibitor
  申请人：BILLICH Andreas

  公开号：US20120172386A1

  公开（公告）日：2012-07-05

  A composition comprising a VEGF receptor inhibitor and a penetration enhancer and uses thereof.
• US8026247B2
  申请人：——

  公开号：US8026247B2

  公开（公告）日：2011-09-27