双吲哚马来酰亚胺II | 137592-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 双吲哚马来酰亚胺II
• 中文别名: 双吲哚马来酰亚胺 II
• 英文名称: Bisindolylmaleimide II
• 英文别名: 3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione
• CAS: 137592-45-1
• 化学式: C₂₇H₂₆N₄O₂
• 分子量: 438.5
• InChiKey: LBFDERUQORUFIN-UHFFFAOYSA-N

物化性质

• 沸点：
  709.9±60.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  70.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SC-β cells and compositions and methods for generating the same
  申请人：President and Fellows of Harvard College

  公开号：US10030229B2

  公开（公告）日：2018-07-24

  Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

  本文公开了用于诱导β细胞成熟的方法、组合物、试剂盒和制剂，以及用于细胞治疗等各种应用的分离的SC-β细胞群。
• SC-beta cells and compositions and methods for generating the same
  申请人：President and Fellows of Harvard College

  公开号：US10655106B2

  公开（公告）日：2020-05-19

  Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

  本文公开了用于诱导β细胞成熟的方法、组合物、试剂盒和制剂，以及用于细胞治疗等各种应用的分离的SC-β细胞群。
• Compositions and methods for promoting the generation of endocrine cells
  申请人：President and Fellows of Harvard College

  公开号：US10941384B2

  公开（公告）日：2021-03-09

  Disclosed herein are compositions and methods for the generation of insulin positive β cells, for example by exposing Pdx+ pancreatic progenitor cells to one or more compounds, and compositions and kits comprising isolated populations of insulin positive cells.

  本文公开了生成胰岛素阳性β细胞的组合物和方法，例如通过将Pdx+胰腺祖细胞暴露于一种或多种化合物，以及包含分离的胰岛素阳性细胞群的组合物和试剂盒。
• Compositions And Methods For Treating Toxoplasmosis, Cryptosporidiosis, And Other Apicomplexan Protozoan Related Diseases
  申请人：VAN VOORHIS Wesley C.

  公开号：US20130018040A1

  公开（公告）日：2013-01-17

  Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii ( T. gondii ) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum ( C. parvum ) and Cryptosporidium hominus ( C. hominus ) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R 1 , and R 3 are defined herein.
• SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
  申请人：President and Fellows of Harvard College

  公开号：US20150218522A1

  公开（公告）日：2015-08-06

  Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.