1H-Imidazole, 2-(4-fluoro-2-methylphenyl)- | 1314907-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1H-Imidazole, 2-(4-fluoro-2-methylphenyl)-
• 英文别名: 2-(4-fluoro-2-methylphenyl)-1H-imidazole
• CAS: 1314907-27-1
• 化学式: C₁₀H₉FN₂
• 分子量: 176.19
• InChiKey: UALPCKZMVIVVBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 2' AND 5' MODIFIED MONOMERS AND OLIGONUCLEOTIDES
  申请人：Rajeev Kallanthottathil G.

  公开号：US20130203836A1

  公开（公告）日：2013-08-08

  The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.