4-phenyl-5-(2-phenylethynyl)-1-propyl-1H-1,2,3-triazole | 1595281-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-phenyl-5-(2-phenylethynyl)-1-propyl-1H-1,2,3-triazole
• 英文别名: 4-Phenyl-5-(2-phenylethynyl)-1-propyltriazole
• CAS: 1595281-88-1
• 化学式: C₁₉H₁₇N₃
• 分子量: 287.364
• InChiKey: AAPQGCIJAWOVQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  溴丙烷 、 苯乙炔 在 sodium azide 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以57%的产率得到4-phenyl-5-(2-phenylethynyl)-1-propyl-1H-1,2,3-triazole
  参考文献：
  名称：

  Cu(BTC)-MOF catalyzed multicomponent reaction to construct 1,4-disubstituted-1,2,3-triazoles

  摘要：

  Cu(BTC)-MOF catalyzed one-pot, three-component reaction of terminal alkynes, halides and sodium azide to form 1,4-disubstituted-1,2,3-triazoles was investigated. It was conducted in methanol under room temperature with good to excellent product yields. The Cu(BTC)-MOF catalyst could be easily recovered by filtration and be reused at least three recycles with no significant decrease in the yield. The method was demonstrated to be a truly green process with sustainability and economics. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2018.05.058

文献信息

• Nano-copper catalyzed three-component reaction to construct 1,4-substituted 1,2,3-triazoles
  作者：Lina Huang、Wei Liu、Juncheng Wu、Ying Fu、Kehu Wang、Congde Huo、Zhengyin Du

  DOI：10.1016/j.tetlet.2014.02.114

  日期：2014.4

  Three-component reaction of alkyl halides, sodium azide with terminal alkynes can be catalyzed by nano-copper particles under ambient conditions. A series of 1,4-disubstituted-1,2,3-triazoles were obtained regioselectively by this one-pot strategy. Nano copper can be reused at least three times without significant deactivation. (C) 2014 Elsevier Ltd. All rights reserved.