ethyl (2-{[(5-isoxazol-3-ylthien-2-yl)sulfonyl]amino}-1,3-thiazol-5-yl)acetate | 532426-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl (2-{[(5-isoxazol-3-ylthien-2-yl)sulfonyl]amino}-1,3-thiazol-5-yl)acetate
• 英文别名: Ethyl 2-[2-[[5-(1,2-oxazol-3-yl)thiophen-2-yl]sulfonylamino]-1,3-thiazol-5-yl]acetate
• CAS: 532426-05-4
• 化学式: C₁₄H₁₃N₃O₅S₃
• 分子量: 399.472
• InChiKey: HHGFQNHZEOJFIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  176
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：BIOVITRUM AB

  公开号：EP1461325A1

  公开（公告）日：2004-09-29
• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2003043999A1

  公开（公告）日：2003-05-30

  The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.