Aplysiasecosterol A, a 9,11-secosteroid, has a unique tricyclic γ-diketone skeleton including a hemiacetal. The concise and efficient synthesis of the tricyclic core was developed by using pseudo-desymmetrizing acetalization and acyl radical cyclization. Toward the total synthesis, the efficient method for the introduction of the D ring part could be developed by using an organocuprate.
Aplysiasecosterol A(9,11-secosteroid)具有独特的
三环γ-二酮骨架,包括
半缩醛。通过使用伪去对称
缩醛化和酰基自由基环化,开发了简洁高效的
三环核的合成方法。为了进行全合成,可以通过使用
有机铜酸盐来开发引入D环部分的有效方法。