4-(4-methyl-1,3-thiazole-5-carbonyl)piperazine | 1016704-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-methyl-1,3-thiazole-5-carbonyl)piperazine
• 英文别名: (4-Methylthiazol-5-yl)(piperazin-1-yl)methanone；(4-methyl-1,3-thiazol-5-yl)-piperazin-1-ylmethanone
• CAS: 1016704-50-9
• 化学式: C₉H₁₃N₃OS
• 分子量: 211.288
• InChiKey: XXYVZAHSDFQMCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  73.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ALICYCLIC HETEROCYCLIC COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1970373A1

  公开（公告）日：2008-09-17

  An alicyclic heterocyclic compound represented by the following formula or a pharmaceutically acceptable salt thereof: wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., P1 and P2 are CH or N, q and r are 0 to 2, X is -NH-, -O-, -CH2-, etc., Y is -CH2-, -CO-, -SO2-, etc., Z is -CO-, -SO2-, etc., and R3 is carbocyclic group, heterocyclic group, hydroxyl, alkoxy or amino, is useful as a controlling agent of the function of CCR4 useful for the prevention or treatment for bronchial asthma, atopic dermatitis, etc.

  以下是该公式表示的脂环杂环化合物或其药用可接受盐： 其中环A是杂环，环B是碳环，杂环等，P1和P2是CH或N，q和r为0至2，X为-NH-，-O-，-CH2-等，Y为- -，-CO-，-SO2-等，Z为-CO-，-SO2-等，R3为碳环基团，杂环基团，羟基，烷氧基或氨基， 可用作CCR4功能的控制剂，用于预防或治疗支气管哮喘，特应性皮炎等。
• NOVEL 9-SUBSTITUTED-5-CARBOXY-OXADIAZINO-QUINOLONE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ANTI-BACTERIALS
  申请人：Ropp Sandrine

  公开号：US20100009980A1

  公开（公告）日：2010-01-14

  A subject of the invention is the compounds of formula (I): wherein R 1 , R 2 , R 3 , R′ 3 , R 4 , R′ 4 , R 5 , R 6 and R 7 are as described in the application, in the form of enantiomers or mixtures, as well as their salts with acids and bases, their preparation and their application as anti-bacterials, in both human and veterinary medicine.

  本发明涉及以下式（I）的化合物：其中R1、R2、R3、R′3、R4、R′4、R5、R6和R7如申请中所述，以对映体或混合物的形式存在，以及它们与酸和碱的盐，它们的制备以及它们作为抗菌剂在人类和兽医医学中的应用。
• HETEROCYCLIC TRPML1 AGONISTS
  申请人：Libra Therapeutics, Inc.

  公开号：EP3821947A1

  公开（公告）日：2021-05-19

  The invention relates to a compound of formula (I) or a stereoisomer thereof, or a salt of any of the foregoing and to processes for its preparation. The compounds of formula (I) are useful in the treatment TRPML1- mediated disorders or diseases.

  该发明涉及公式(I)的化合物或其立体异构体，或任何上述化合物的盐，以及其制备的过程。公式(I)的化合物在治疗TRPML1介导的疾病或疾病中有用。
• 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
  申请人：VETOQUINOL S.A.

  公开号：EP2145891A1

  公开（公告）日：2010-01-20

  A subject of the invention is the compounds of formula (I): wherein R1, R2, R3, R'3, R4, R'4, R5, R6 and R7 are as described in the application, in the form of enantiomers or mixtures, as well as their salts with acids and bases, their preparation and their application as anti-bacterials, in both human and veterinary medicine.

  本发明的一个主题是式（I）化合物： 其中 R1、R2、R3、R'3、R4、R'4、R5、R6 和 R7 如本申请所述、 以对映体或混合物的形式存在，以及它们与酸和碱的盐类、它们的制备和它们作为抗菌剂在人类和兽医中的应用。
• US8071590B2
  申请人：——

  公开号：US8071590B2

  公开（公告）日：2011-12-06