N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-thioxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide | 501432-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-thioxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide
• 英文别名: N-[(4-chlorophenyl)methyl]-2-[[[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylamino]methyl]-7-methyl-4-sulfanylidenethieno[2,3-b]pyridine-5-carboxamide
• CAS: 501432-75-3
• 化学式: C₂₆H₂₆ClN₃O₃S₂
• 分子量: 528.096
• InChiKey: HRTRJKGIVHPOSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents
  申请人：——

  公开号：US20030109542A1

  公开（公告）日：2003-06-12

  The invention provides a compound of formula I: 1 wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection, atherosclerosis or restenosis using such compounds or salts.

  该发明提供了公式I的化合物：1其中R1、R2、R3和R4具有规范中定义的任何值，或其药学上可接受的盐，以及用于制备这种化合物或盐的过程和中间体，以及使用这种化合物或盐治疗疱疹病毒感染、动脉粥样硬化或再狭窄的方法。
• 4-THIOXO-4,7-DIHYDRO-THIENO 2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
  申请人：Pharmacia & Upjohn Company

  公开号：EP1421089A1

  公开（公告）日：2004-05-26
• US6620810B2
  申请人：——

  公开号：US6620810B2

  公开（公告）日：2003-09-16
• [EN] 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANT IVIRAL AGENTS<br/>[FR] 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOXAMIDES EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2003020729A1

  公开（公告）日：2003-03-13

  The invention provides a compound of formula (I), wherein R?1, R2, R3, and R4¿ have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods for treating a herpesvirus infection, atherosclerosis or restenosis a using such compounds or salts.