N-cyclohexyl-N-[[4-fluoro-3-[4-(trifluoromethoxy)phenyl]phenyl]methyl]-1-methyl-1,2,4-triazole-3-carboxamide | 1262237-15-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-cyclohexyl-N-[[4-fluoro-3-[4-(trifluoromethoxy)phenyl]phenyl]methyl]-1-methyl-1,2,4-triazole-3-carboxamide
• CAS: 1262237-15-9
• 化学式: C₂₄H₂₄F₄N₄O₂
• 分子量: 476.474
• InChiKey: MUMFTRAEVOQUEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60.2
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• GLYCINE TRANSPORTER INHIBITORS
  申请人：Yasuhara Akito

  公开号：US20120116095A1

  公开（公告）日：2012-05-10

  The present invention aims to provide novel compounds represented by formula [I] or pharmaceutically acceptable salts thereof: which are useful for prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, convulsion, tremor, pain, or sleep disorders, based on their inhibitory effect against glycine uptake.

  本发明旨在提供由式[I]表示的新化合物或其药学上可接受的盐：这些化合物对于预防或治疗类似精神分裂症、阿尔茨海默病、认知障碍、痴呆、焦虑症（例如广泛性焦虑障碍、惊恐障碍、强迫症、社交焦虑障碍、创伤后应激障碍、特定恐惧症、急性应激障碍）、抑郁症、药物依赖、惊厥、震颤、疼痛或睡眠障碍具有抑制甘氨酸摄取的作用。