(S)-2-Benzyl-2-fluoro-N-(4-methoxy-phenyl)-malonamic acid | 141514-71-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (S)-2-Benzyl-2-fluoro-N-(4-methoxy-phenyl)-malonamic acid
• CAS: 141514-71-8
• 化学式: C₁₇H₁₆FNO₄
• 分子量: 317.317
• InChiKey: OXQUGAYLOBWVBL-KRWDZBQOSA-N

物化性质

• 沸点：
  545.0±50.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 (S)-2-Benzyl-2-fluoro-N-(4-methoxy-phenyl)-malonamic acid 以 乙醚 为溶剂， 生成 (S)-2-Benzyl-2-fluoro-N-(4-methoxy-phenyl)-malonamic acid methyl ester
  参考文献：
  名称：

  Use of 1,3-Dioxin-4-ones and Their Related Compounds in Synthesis. Part 35. Synthesis of Optically Pure Fluoromalonamic Acids by Means of Asymmetric Fluorination of Chiral 1,3-Oxazine-4,6-diones

  摘要：

  Fluorination of chiral 5-substituted 1,3-oxazine-4,6-dione derivatives proceeded stereoselectively to give the 5-fluorooxazinediones, which were readily transformed to optically pure fluoromalonamic acids.

  DOI：

  10.3987/com-91-s33
• 作为产物：
  描述：

  (3S,6R,7S,10R)-3-Benzyl-3-fluoro-7-isopropyl-5-(4-methoxy-phenyl)-10-methyl-1-oxa-5-aza-spiro[5.5]undecane-2,4-dione 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 (S)-2-Benzyl-2-fluoro-N-(4-methoxy-phenyl)-malonamic acid
  参考文献：
  名称：

  Use of 1,3-Dioxin-4-ones and Their Related Compounds in Synthesis. Part 35. Synthesis of Optically Pure Fluoromalonamic Acids by Means of Asymmetric Fluorination of Chiral 1,3-Oxazine-4,6-diones

  摘要：

  Fluorination of chiral 5-substituted 1,3-oxazine-4,6-dione derivatives proceeded stereoselectively to give the 5-fluorooxazinediones, which were readily transformed to optically pure fluoromalonamic acids.

  DOI：

  10.3987/com-91-s33