2,2'-oxybis(ethane-2,1-diyl) bis(1H-imidazole-1-carboxylate) | 1375482-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,2'-oxybis(ethane-2,1-diyl) bis(1H-imidazole-1-carboxylate)
• 英文别名: 2-[2-(Imidazole-1-carbonyloxy)ethoxy]ethyl imidazole-1-carboxylate
• CAS: 1375482-34-0
• 化学式: C₁₂H₁₄N₄O₅
• 分子量: 294.267
• InChiKey: KXJGJAVAHXTWJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N,N'-羰基二咪唑 、 二乙二醇 以 氯仿 为溶剂， 以39%的产率得到2,2'-oxybis(ethane-2,1-diyl) bis(1H-imidazole-1-carboxylate)
  参考文献：
  名称：

  Rendering Protein-Based Particles Transiently Insoluble for Therapeutic Applications

  摘要：

  Herein, we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.

  DOI：

  10.1021/ja302363r

文献信息

• [EN] NANOPARTICLE, LIPOSOMES, POLYMERS, AGENTS AND PROTEINS MODIFIED WITH REVERSIBLE LINKERS<br/>[FR] NANOPARTICULES, LIPOSOMES, POLYMÈRES, AGENTS ET PROTÉINES MODIFIÉS AVEC DES LIEURS RÉVERSIBLES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2012112689A1

  公开（公告）日：2012-08-23

  Pharmaceutical, chemical and biological agents containing a reversible disulfide linker are described. These agents can also be covalently bound or contained in delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain an agent having a reversible disulfide linker and to vehicles that are covalently linked to the agent containing a reversible disulfide linker. The modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting while the reversibility of the linker can leave the agent to which it is attached free from residual chemical groups after being reduced.

  描述了含有可逆二硫键的药物、化学物质和生物制剂。这些制剂也可以共价结合或包含在传递载体中，以将制剂传递到所需的靶标或区域。还描述了含有可逆二硫键的制剂的传递载体，以及与含有可逆二硫键的制剂共价结合的载体。本文描述的修饰可以改变制剂和载体的性质，从而提供所需的溶解性、稳定性、疏水性和靶向性，而连接物的可逆性可以使其附着的制剂在还原后不受残留化学基团的影响。
• NANOPARTICLE, LIPOSOMES, POLYMERS, AGENTS AND PROTEINS MODIFIED WITH REVERSIBLE LINKERS
  申请人：DeSimone Joseph M.

  公开号：US20140081012A1

  公开（公告）日：2014-03-20

  Pharmaceutical, chemical and biological agents containing a reversible disulfide linker are described. These agents can also be covalently bound or contained in delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain an agent having a reversible disulfide linker and to vehicles that are covalently linked to the agent containing a reversible disulfide linker. The modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting while the reversibility of the linker can leave the agent to which it is attached free from residual chemical groups after being reduced.

  本文描述了含有可逆二硫键连接剂的制药、化学和生物制剂。这些制剂也可以共价结合或包含在传递载体中，以将制剂传递到所需的目标或区域。还描述了包含具有可逆二硫键连接剂的制剂的传递载体，以及与含有可逆二硫键连接剂的制剂共价链接的载体。本文所描述的修饰可以修改制剂和载体的性质，从而提供所需的溶解度、稳定性、疏水性和定向性，而连接剂的可逆性可以使其附着的制剂在还原后不留下残留的化学基团。