1-phenyl-2,3-dihydro-1H-indene-1,2-diol | 1224455-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-phenyl-2,3-dihydro-1H-indene-1,2-diol
• 英文别名: 1-Phenyl-2,3-dihydroindene-1,2-diol
• CAS: 1224455-17-7
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: YQDJQYVIHZYJSE-UHFFFAOYSA-N

物化性质

• 熔点：
  107 °C
• 沸点：
  379.2±42.0 °C(Predicted)
• 密度：
  1.292±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-phenyl-2,3-dihydro-1H-indene-1,2-diol 在 sodium periodate 作用下， 以 甲醇 、 水 为溶剂， 反应 0.5h， 生成 2-(2-苯甲酰基苯基)乙醛
  参考文献：
  名称：

  （2-羟乙基）二苯甲酮可光去除保护基团中的结构反应关系

  摘要：

  为了改善母体的反应性，进行了取代基对（2-羟乙基）二苯甲酮的酯光化学转化为羧酸的影响的详细研究，这是几十年前首次报道的。制备了20多种衍生物，其中10种表现出一定程度的光化学反应性，但没有一个比原始的有明显的改善。该反应对作为致敏剂的噻吨酮或包含碱以促进消除反应均无反应。除全氟苯基类似物外，该溶剂对反应的影响似乎很小，该全氟苯基类似物在己烷中完全不反应，但在甲醇或乙腈中则表现正常。这些被忽略的保护基即使在长波长照射下也可以相当快速地脱保护，仍然可以用于有机合成中。

  DOI：

  10.1016/j.tet.2010.02.087
• 作为产物：
  描述：

  1-hydroxy 1-phenyl indane 在 四氧化锇 、 三氟化硼乙醚 、 N-甲基吗啉氧化物 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 叔丁醇 为溶剂， 生成 1-phenyl-2,3-dihydro-1H-indene-1,2-diol
  参考文献：
  名称：

  取代的4-芳酰基-1-茚满酮和5-芳酰基-1-丁酮的合成

  摘要：

  通过一系列合理的转化，从1-茚满酮1以高收率制备了数个取代的4-芳酰基-1-茚满酮2和5-芳酰基-1-四氢萘酮3。

  DOI：

  10.1002/jccs.201190030

文献信息

• Catalytic process for preparing bisphenol A
  申请人：Neumann Rainer

  公开号：US20050177006A1

  公开（公告）日：2005-08-11

  The present invention relates to a process for preparing bisphenol A in which the phenol and acetone are reacted to give bisphenol A in the presence of a sulfonic acid ion-exchanger in at least one reactor, and in which the reactor, at the time when it is started up, is filled with sulfonic acid ion-exchanger with a bulk volume of 30 to 70 vol. % of the total reactor volume.

  本发明涉及一种制备双酚A的方法，其中在至少一个反应器中，在磺酸型离子交换剂的存在下，将苯酚和丙酮反应以产生双酚A，并且在启动反应器时，反应器内充满了体积为总反应器体积的30%至70%的磺酸型离子交换剂。
• Production of bisphenol-A with reduced sulfur content
  申请人：Neumann Rainer

  公开号：US20050215833A1

  公开（公告）日：2005-09-29

  A process for the production of bisphenol-A having low concentration of sulphur is disclosed. The process comprise a) reacting phenol with acetone in the presence of a sulfonic acid ion exchanger to form a product mixture containing water, bisphenol-A/phenol adduct, phenol and sulfurous particles, and b) filtering the product mixture to separate the sulfurous particles to obtain a purified product mixture that contains water, phenol and bisphenol-A/phenol adduct. In one embodiment of the process further comprise distilling the purified product mixture to remove the water to obtain a first material system that contains said adduct and phenol, crystallizing the adduct, and removing the phenol by filtration using a filtering apparatus to obtain crystalline adduct. In a yet additional embodiment the process comprise crystallizing the purified product mixture to obtain a second material system that contains crystalline adduct, water and phenol and removing the phenol and water by filtration using a filtering apparatus to obtain crystalline adduct.

  本发明揭示了一种生产低硫双酚A的方法。该方法包括a)在磺酸树脂离子交换剂的存在下，将苯酚与丙酮反应，形成含水、双酚A/苯酚加合物、苯酚和含硫颗粒的产物混合物；b)过滤产物混合物以分离含硫颗粒，以获得含水、苯酚和双酚A/苯酚加合物的纯化产物混合物。在该方法的一个实施例中，进一步包括蒸馏纯化产物混合物，以去除水，获得含有所述加合物和苯酚的第一物质体系，结晶加合物，并使用过滤装置通过过滤去除苯酚，以获得结晶加合物。在另一个实施例中，该方法包括结晶纯化产物混合物，以获得含有结晶加合物、水和苯酚的第二物质体系，并使用过滤装置通过过滤去除苯酚和水，以获得结晶加合物。
• CRYSTALLIZATION PROCESSES FOR PRODUCING BISPHENOLS
  申请人：Munnich Christian

  公开号：US20080200734A1

  公开（公告）日：2008-08-21

  Processes for producing bisphenols (e.g., bisphenol A (BPA)) having a purity greater than 99.7% are described, such processes including reacting a phenol and acetone in the presence of an acidic catalyst to form a product mixture comprising a bisphenol; removing at least a portion of the bisphenol from the product mixture in the form of a bisphenol/phenol adduct by crystallization, filtration and washing to provide bisphenol/phenol adduct crystals; and removing at least a portion of the phenol from the bisphenol/phenol adduct crystals to provide the bisphenol having a purity of more than 99.7%; wherein the crystallization comprises continuous suspension crystallization and is carried out in at least three crystallization devices arranged such that the product mixture is first cooled in a first stage of the crystallization to a temperature of 50 to 70° C. in a first crystallization device and a second crystallization device connected in parallel, and subsequently cooled in a second stage of the crystallization to a temperature of 40 to 50° C. in a third crystallization device connected downstream in series to the first and second crystallization devices, and wherein a total dwell time of the product mixture in the crystallization is more than 4 hours.

  本文描述了制备纯度高于99.7％的双酚（例如双酚A（BPA））的工艺，其中包括在酸性催化剂存在下反应苯酚和丙酮，形成包含双酚的产物混合物；通过结晶、过滤和洗涤从产物混合物中至少去除一部分双酚，形成双酚/苯酚加合物晶体；并从双酚/苯酚加合物晶体中至少去除一部分苯酚，以提供纯度超过99.7％的双酚；其中结晶包括连续悬浮结晶，并在至少三个结晶装置中进行，使得产物混合物首先在第一和第二个并联的结晶装置中冷却至50至70℃的温度，在第三个串联的结晶装置中冷却至40至50℃的温度的第二个阶段，产物混合物在结晶中的总停留时间超过4小时。
• Process for the separation of phenol from phenol-containing streams from the preparation of bisphenol A
  申请人：Prein Michael

  公开号：US20060004234A1

  公开（公告）日：2006-01-05

  A continuous process for the separation of phenol is disclosed. The process includes (a) feeding a stream of material containing 40 to 90% phenol, 5 to 40% bisphenol A and 5 to 40% of side products into a distillation column containing at least 5 theoretical separation stages, b) distilling-off the phenol as a top product and discharging from the column a first portion of the bottom product c) continuously introducing a second portion of the bottom product into a dwell-time container operating at process parameters sufficient to cause, in the presence of an acidic catalyst, an at least partial isomerization of the side products to form an isomerized product and d) introducing the isomerized product to the distillation column. The introducing of said portion of the bottom product is at a rate, in Kg/hour, that is more than 30% of the rate of feeding of the stream, and said process parameters include temperatures greater than 190° C. and hydrodynamic dwell time of at least 120 minutes. The said stream of material is produced in the course of preparing bisphenol A by reacting phenol with acetone.

  揭示了一种分离苯酚的连续过程。该过程包括（a）将含有40％至90％苯酚，5％至40％双酚A和5％至40％副产物的物料流送入至少具有5个理论分离级的蒸馏塔中，（b）将苯酚蒸馏出作为顶部产品，并从底部产品中排放第一部分，（c）连续将底部产品的第二部分引入在过程参数下操作的停留时间容器中，在酸性催化剂的存在下，至少部分异构化副产物形成异构产物，（d）将异构产物引入蒸馏塔中。所述底部产品的引入速率为每小时千克，其比物料流的进料速率高30％以上，所述过程参数包括大于190°C的温度和至少120分钟的流体停留时间。所述物料流在制备双酚A的过程中通过苯酚与丙酮反应而产生。
• Process for the preparation of high-purity bisphenol A
  申请人：Blaschke Ulrich

  公开号：US20070004941A1

  公开（公告）日：2007-01-04

  A process for the preparation of high purity bisphenol A is disclosed. The multi-step process entails a process whereby bisphenol A of a purity of preferably at least 99.8% can be obtained.

  公开了一种制备高纯度双酚A的方法。这个多步骤的过程包括一种方法，可以获得至少99.8％的纯度的双酚A。