2-(3-chlorophenyl)-3-[1-[2-(3-chlorophenyl)-1H-indol-3-yl]ethenyl]-1H-indole | 1309945-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(3-chlorophenyl)-3-[1-[2-(3-chlorophenyl)-1H-indol-3-yl]ethenyl]-1H-indole
• CAS: 1309945-75-2
• 化学式: C₃₀H₂₀Cl₂N₂
• 分子量: 479.408
• InChiKey: FWBWJDOFRXFKLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  31.6
• 氢给体数：
  2
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-(3-chlorophenyl)-1H-indole 、 乙酰氯 在 aluminum (III) chloride 、 硝基乙烷 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 以20%的产率得到
  参考文献：
  名称：

  Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity

  摘要：

  2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC50 of 13.0-17.0 mu M. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.028

文献信息

• Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity
  作者：Madhumita Mandal、Deepak Kumar、Rajneeta Roy、Rupashree Sen、Padma Das、Mitali Chatterjee、Parasuraman Jaisankar

  DOI：10.1016/j.bmcl.2011.03.028

  日期：2011.5

  2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC50 of 13.0-17.0 mu M. (C) 2011 Elsevier Ltd. All rights reserved.