6-(N-carboxymethylamino)caproate | 90159-86-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-(N-carboxymethylamino)caproate
• 英文别名: 6-[(Carboxymethyl)amino]hexanoic acid；6-(carboxymethylamino)hexanoic acid
• CAS: 90159-86-7
• 化学式: C₈H₁₅NO₄
• 分子量: 189.211
• InChiKey: TUOBABBAWKYTHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-溴己酸甲酯 、 肌氨酸 、 sodium;hydride 以to afford the 6-[(carboxymethyl)amino]hexanoic acid的产率得到6-(N-carboxymethylamino)caproate
  参考文献：
  名称：

  6-(N-carboxymethylamino)caproate, salts thereof and methods of use

  摘要：

  在生产和分析单克隆抗体高级糖基化终产物时有用的化合物是公式为XO.sub.2 C--(CH.sub.2).sub.5--NH--CH.sub.2 CO.sub.2 X (I)的6-(N-羧甲基氨基)己酸盐，其中X是氢或碱金属盐阳离子。这些化合物可以用于生产这种单克隆抗体，并评估为诊断目的而制备的AGE抗体的纯度和反应性。

  公开号：

  US05869527A1

文献信息

• Compositions comprising amino and diamino acid derivatives and use thereof as plant growth stimulants
  申请人：S.I.P.C.A.M. S.p.A. Società Italiana Prodotti Chimici e per l'Agricoltura Milano

  公开号：EP0101588A1

  公开（公告）日：1984-02-29

  Amino and diamino acid derivatives having the formula: where: R can be NH2- or A-O-C, A being hydrogen, an alkaline metal, an amino or ammonic radical or an aliphatic radical; n is a whole number between 2 and 5; X is hydrogen or a lower alkyl radical with 1-4 carbon atoms; R1 is hydrogen, an alkaline metal, an amino or ammonic, radical or an aliphatic radical; can be prepared by condensing diamines or omega-amino acids, or their lactams or aliphatic esters, with alpha-halogenated lower aliphatic acids or with their aliphatic esters, with possible subsequent salification with alkaline hydrates or with amino or ammonic compounds or with esterification with aliphatic alcohols. Such compounds are used as plant growth stimulants or as pharmaceutical products.

  具有以下式子的氨基酸和二氨 酸衍生物 其中R 可以是 NH2- 或 A-O-C、 A 可以是氢、碱金属、氨基或氨自由基或脂肪族自由基； n 是介于 2 和 5 之间的整数； X 是氢或含 1-4 个碳原子的低级烷基； R1 是氢、碱金属、氨基或氨自由基或脂肪族自由基； 可通过二元胺或欧米伽氨基酸或其内酰胺或脂肪族酯与α-卤化低级脂肪族酸或其脂肪族酯缩合制备，随后可与碱性水合物或氨基或氨化合物盐化，或与脂肪族醇酯化。 此类化合物可用作植物生长刺激剂或医药产品。
• Detection of advanced glycation endproducts in a cerebrospinal fluid sample
  申请人：Roche Diagnostics GmbH

  公开号：EP1217378A1

  公开（公告）日：2002-06-26

  The invitation relates to methods for measurement of at least one advanced glycation endproduct (AGE) in a cerebrospinal fluid (CSF) sample that has been pre-treated with a protease, detergent or chaotropic agent and to the use of these methods in the assessment of neurodegenerative disease.

  该邀请涉及测量经蛋白酶、洗涤剂或混沌剂预处理的脑脊液（CSF）样本中至少一种高级糖化终产物（AGE）的方法，以及将这些方法用于评估神经退行性疾病的方法。
• Reagents and solid phase components in specific binding assays free of advanced glycosylation endproducts
  申请人：Roche Diagnostics GmbH

  公开号：EP1243924A1

  公开（公告）日：2002-09-25

  The present invention relates to the field of detection and measurement of advanced glycosylation endproducts (AGEs), in particular to methods of selection and/or quality control of a reagent or a coated solid phase component appropriate for AGE-assays. It also relates to a process for production of an AGE-free solid phase component, the solid phase component, and to the use of such solid phase component.

  本发明涉及晚期糖基化终产物（AGEs）的检测和测量领域，特别是涉及适合 AGE 分析的试剂或涂布固相组分的选择和/或质量控制方法。它还涉及一种不含 AGE 的固相组分、固相组分的生产工艺以及这种固相组分的使用。
• MONOCLONAL ANTIBODIES SPECIFIC FOR ADVANCED GLYCOSYLATION ENDPRODUCTS IN BIOLOGICAL SAMPLES
  申请人：ALTEON Inc.

  公开号：EP0801658B1

  公开（公告）日：2003-07-16
• Method for the selection of reagents and solid phase components in specific binding assays free of advanced glycosylation endproducts
  申请人：Roche Diagnostics GmbH

  公开号：EP1243924B1

  公开（公告）日：2004-11-24