Bis(2-hydroxyethyl) but-2-enedioate | 45125-84-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Bis(2-hydroxyethyl) but-2-enedioate
• CAS: 45125-84-6
• 化学式: C₈H₁₂O₆
• 分子量: 204.18
• InChiKey: SMPWDQQFZPIOGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙烯酸羟乙酯 在 Hoveyda-Grubbs catalyst second generation 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 Bis(2-hydroxyethyl) but-2-enedioate
  参考文献：
  名称：

  Halide exchanged Hoveyda-type complexes in olefin metathesis

  摘要：

  本文的目的是介绍带有溴和碘配体的第二代Hoveyda型烯烃转化催化剂的简单合成，并揭示不同阴离子配体对环开放重聚合、环闭合重聚合、enyne环异构化和交叉重聚合反应催化性能的微妙影响。

  DOI：

  10.3762/bjoc.6.125

文献信息

• [EN] POLYGLYOXYLATES, MANUFACTURE AND USE THEREOF<br/>[FR] POLYGLYOXYLATES, LEUR PRODUCTION ET LEUR UTILISATION
  申请人：UNIV WESTERN ONTARIO

  公开号：WO2015168809A1

  公开（公告）日：2015-11-12

  Self-immolative polymers degrade by an end-to-end depolymerisation mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.

  自焚式聚合物通过从聚合物末端切割稳定端盖，以端到端解聚机制进行降解。例如包括均聚物、混合聚合物包括区块共聚物，适用于各种应用。聚乙二醇酸可以端接或与连接剂如区块共聚物一样封端。
• PRODRUGS OF MONOMETHYL FUMARATE (MMF)
  申请人：RATIOPHARM GMBH

  公开号：US20150299103A1

  公开（公告）日：2015-10-22

  The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.

  本发明涉及新型化合物作为药物的用途。具体而言，本发明涉及新型丙烯酸单甲酯（MMF）的前药，适用于药物，优选用于治疗和/或预防全身性疾病，自身免疫性疾病，炎症性疾病，例如多发性硬化和牛皮癣。
• A paper coating composition and its production
  申请人：Sumitomo Naugatuck Co., Ltd.

  公开号：EP0013031A1

  公开（公告）日：1980-07-09

  A coating composition for paper comprising a mineral pigment and a polymer latex prepared by emulsion polymerization of an aliphatic conjugated diene monomer, an ethylenically unsaturated carboxylic acid monomer and a monoolefinic monomer in a weight proportion of 24.5 - 50 : 0.5 -5 : 45 - 75 in the presence of a chain transfer agent, characterized in that the chain transfer agent is carbon tetrachloride and an alkylmercaptan in combination.

  一种用于纸张的涂料组合物，包括矿物颜料和聚合物胶乳，聚合物胶乳是由脂肪族共轭二烯单体、乙烯基不饱和羧酸单体和单烯烃单体在有链转移剂存在的情况下，以 24.5 - 50 : 0.5 -5 : 45 - 75 的重量比例进行乳液聚合制备而成，其特征在于链转移剂是四氯化碳和烷基硫醇的混合物。
• A process for forming a coating film
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：EP0036621A1

  公开（公告）日：1981-09-30

  A process for forming a coating film comprising coating, onto a substrate, a solvent type coating material prepared by blending a color pigment or combination of a metallic powder and a color pigment into base resin (A) containing a carboxylic acid amide copolymer as main component, then coating a transparent thermosetting powder coating material thereon, and thereafter heating and curing them.

  一种形成涂膜的工艺，包括在基材上涂覆一种溶剂型涂层材料，该材料是通过将彩色颜料或金属粉末与彩色颜料的混合物混合到以羧酸酰胺共聚物为主要成分的基础树脂（A）中制备而成，然后在其上涂覆一种透明的热固性粉末涂料，接着对其进行加热和固化。
• Monomer compositions comprising dicyclopentenyloxyalkyl ester and drying oil ester and coating compositions containing them
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0045136A2

  公开（公告）日：1982-02-03

  Monomer compositions comprise: (a) from 1 to 99% by weight of monomer of at least one dicyclopentenyloxyalkyl ester of polymerizable ethylenically unsaturated monocarboxylic or dicarboxylic acid, and (b) from 1 to 99% by weight of monomer of at least one drying oil or semi-drying oil ester having ethylenically unsaturated addition polymerisable functionality in the ester moiety. The compositions may be used as reactive diluents in coating and/or impregnating compositions comprising (1) from 5 to 75% by weight of the monomer composition (2) from 95 to 25% by weight, based on the weight of components (1) and (2), of a film-forming component comprising at least one of: drying oil; alkyd resins having autoxidative functionality; vinyl addition polymers with drying oil functionality; film-forming binders lacking any appreciable inherent autoxidizable functionality; and- condensation polymers modified with acrylate or methacrylate functionality; (3) a polyvalent metal-containing complex or salt that catalyzes the autoxidative curing of components (1) and (2), and, optionally, (4) a volatile oxime stabilizer.

  单体组合物包括 (a) 至少一种可聚合乙烯基不饱和单羧酸或二羧酸的二环戊烯氧基烷基酯的单体（重量百分比为 1%至 99%），以及 (b) 至少一种干燥油或半干燥油酯的单体（按重量计），其酯分子中具有乙烯基 不饱和加成聚合官能团。 这些组合物可用作涂层和/或浸渍组合物中的反应性稀释剂，其中包括 (1) 5% 至 75% （重量百分比）的单体组合物 (2) 95% 至 25% （重量百分比）的成膜成分（以成分(1)和(2)的重量为基准），成膜成分包括以下至少一种： 干燥油；醇酸树脂；乙烯基不饱和聚合酯：干燥油；具有自氧化官能性的醇酸树脂；具有干燥油官能性的乙烯基加成聚合物； 缺乏任何明显固有可自氧化官能性的成膜粘合剂；以及- 具有丙烯酸酯或甲基丙烯酸酯官能性改性的缩合聚合物； (3) 可催化组分 (1) 和 (2) 自氧化固化的含多价金属的络合物或盐，以及 (4) 挥发性肟稳定剂。