| 951000-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 951000-50-3
• 化学式: C₁₆H₁₂FNS
• 分子量: 269.342
• InChiKey: LEFHMRJSHBTKKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  12.89
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  4-(4-甲基苯基)-2-苯基-1,3-噻唑 在 Accufluor(R) 作用下， 以 乙腈 为溶剂， 以40%的产率得到
  参考文献：
  名称：

  Nuclear fluorination of 2,4-diarylthiazoles with Accufluor®

  摘要：

  A series of 2,4-diphenylthiazole derivatives were synthesized and directly fluorinated at the 5-position by reaction with the N-F fluorinating reagent Accufluor (R). Although fluorination occurred selectively at the thiazole ring, it was always incomplete and thus yields for the novel fluorinated products were low to moderate (19-43%) following purification to remove starting material. Nonetheless, the target compounds were obtained in a convenient and straightforward manner. Selectfluor (R) was not as effective as Accufluor (R) as it gave a trace amount of the 5-chlorothiazole that was difficult to remove by chromatography. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.08.007