3-(3,4-dimethylphenyl)-5-[3-(3-cyclopentyloxy-4-methoxyphenyl)-5-methyl-4,5-dihydro-isoxazol-5-yl]-[1,2,4]oxadiazole | 853582-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(3,4-dimethylphenyl)-5-[3-(3-cyclopentyloxy-4-methoxyphenyl)-5-methyl-4,5-dihydro-isoxazol-5-yl]-[1,2,4]oxadiazole
• 英文别名: 5-[3-(3-cyclopentyloxy-4-methoxyphenyl)-5-methyl-4H-1,2-oxazol-5-yl]-3-(3,4-dimethylphenyl)-1,2,4-oxadiazole
• CAS: 853582-31-7
• 化学式: C₂₆H₂₉N₃O₄
• 分子量: 447.534
• InChiKey: IOPASDCAMPIVBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  79
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• PHOSPHODIESTERASE INHIBITORS
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1694655A2

  公开（公告）日：2006-08-30
• [EN] PHOSPHODIESTERASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIESTÉRASE
  申请人：RANBAXY LAB LTD

  公开号：WO2005051931A2

  公开（公告）日：2005-06-09

  The present invention relates to isoxazoline derivatives of structure (I) and their analogues, which can be used as phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.