4-[2-(4-fluoro-phenylamino)-oxazol-5-yl]-benzonitrile | 1056165-15-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[2-(4-fluoro-phenylamino)-oxazol-5-yl]-benzonitrile
• 英文别名: 4-[2-(4-fluoroanilino)-1,3-oxazol-5-yl]benzonitrile
• CAS: 1056165-15-1
• 化学式: C₁₆H₁₀FN₃O
• 分子量: 279.273
• InChiKey: PSWMVPCVEWINBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases
  申请人：Cheruvallath S. Zacharia

  公开号：US20060135483A1

  公开（公告）日：2006-06-22

  Compounds, pharmaceutical compositions, and methods for treating, preventing, or ameliorating symptoms associated with diseases such as diabetes, cancer, neurodegenerative diseases, and obesity are provided. The compounds and compositions inhibit protein tyrosine phosphatase enzymes, e.g., PTP-1B.

  提供了化合物、药物组合物和治疗、预防或改善与糖尿病、癌症、神经退行性疾病和肥胖症等疾病相关症状的方法。这些化合物和组合物抑制蛋白酪氨酸磷酸酶酶，例如PTP-1B。
• OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES
  申请人：Cengent Therapeutics, Inc.

  公开号：EP1786421A2

  公开（公告）日：2007-05-23
• [EN] OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES<br/>[FR] INHIBITEURS DE TYROSINE PHOSPHATASES A HETEROCYCLE OXYGENE/AZOTE
  申请人：CENGENT THERAPEUTICS INC

  公开号：WO2006017124A2

  公开（公告）日：2006-02-16

  Compounds, pharmaceutical compositions, and methods for treating, preventing, or ameliorating symptoms associated with diseases such as diabetes, cancer, neurodegenerative diseases, and obesity are provided. The compounds and compositions inhibit protein tyrosine phosphatase enzymes, e.g., PTP-1B.