6-β-(4'-trifluoromethyl)-N-methylbenzamido-14-hydroxy-17-(cyclopropylmethyl)nordesmorphine | 1204240-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 6-β-(4'-trifluoromethyl)-N-methylbenzamido-14-hydroxy-17-(cyclopropylmethyl)nordesmorphine
• 英文别名: N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-4-(trifluoromethyl)benzamide
• CAS: 1204240-08-3
• 化学式: C₂₉H₃₁F₃N₂O₄
• 分子量: 528.571
• InChiKey: YQIAWCIKPHGCLL-RDGDOILBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-β-(4'-trifluoromethyl)-N-methylbenzamido-14-hydroxy-17-(cyclopropylmethyl)nordesmorphine 、 草酸 以 甲醇 为溶剂， 生成 6-β-(4'-trifluoromethyl)-N-methylbenzamido-14-hydroxy-17-(cyclopropylmethyl)nordesmorphine oxalate
  参考文献：
  名称：

  [EN] SYNTHESIS OF METABOLICALLY STABLE AGENTS FOR ALCOHOL AND DRUG ABUSE
  [FR] SYNTHÈSE D'AGENTS MÉTABOLIQUEMENT STABLES POUR L'ALCOOLISME ET LA TOXICOMANIE

  摘要：

  本文披露了式（I）的化合物；如本文所定义，或其药用可接受的盐，包括相同的药物组合物，以及使用这些化合物治疗物质成瘾的方法。

  公开号：

  WO2010006119A1

文献信息

• STABLE TABLET CONTAINING 4,5-EPOXYMORPHINAN DERIVATIVE
  申请人：Ohta Kotoe

  公开号：US20120114752A1

  公开（公告）日：2012-05-10

  The present invention relates to a stable tablet comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the tablet according to the present invention comprises: (1) as the effective ingredient, a specific 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt; (2) sodium thiosulfate; (3) at least one selected from the group consisting of saccharides and sugar alcohols; and (4) crospovidone, sodium carboxymethyl starch or a mixture thereof, in which tablet the content of the aforementioned (4) is 1 to 20% by weight per unit weight containing the aforementioned effective ingredient.