2-[4-(3-methoxy-trans-1-propen-1-yl)phenyl]-4,5-bis (4-pyrrolidinophenyl) imidazole | 216227-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(3-methoxy-trans-1-propen-1-yl)phenyl]-4,5-bis (4-pyrrolidinophenyl) imidazole
• 英文别名: 2-[4-[(E)-3-methoxyprop-1-enyl]phenyl]-4,5-bis(4-pyrrolidin-1-ylphenyl)-1H-imidazole
• CAS: 216227-23-5
• 化学式: C₃₃H₃₆N₄O
• 分子量: 504.675
• InChiKey: CHFRBISONFSQPR-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Use of imidazole derivatives as MDR modulators
  申请人：Taiji Biomedical, Inc.

  公开号：EP2082740A2

  公开（公告）日：2009-07-29

  The invention relates to the use of imidazole derivatives having formula (I) or their pharmaceutically acceptable salts for treating tumor cells and for increasing the sensitivity of multidrug resistant tumor cells to antitumor chemotherapeutic agents.

  本发明涉及具有式 (I) 的咪唑衍生物的用途 或其药学上可接受的盐类用于治疗肿瘤细胞和提高耐多药肿瘤细胞对抗肿瘤化疗药物的敏感性。
• IMIDAZOLE DERIVATIVES AS MDR MODULATORS
  申请人：Taiji Biomedical, Inc.

  公开号：EP0999835B1

  公开（公告）日：2009-09-09
• METHODS OF ENHANCING CHEMOTHERAPY
  申请人：Taiji Biomedical, Inc.

  公开号：EP1221847B1

  公开（公告）日：2009-03-25
• Methods & Compositions For Enhancing Pharmaceutical Treatments
  申请人：Newman J. Michael

  公开号：US20070203215A1

  公开（公告）日：2007-08-30

  Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.
• Compositions and Methods for Treating Lysosomal Disorders
  申请人：Lingwood Clifford A.

  公开号：US20130012539A1

  公开（公告）日：2013-01-10

  The present invention provides compositions and methods for treating lysosomal disorders using a class of substituted imidazole derivatives or compounds.