4(5)-(2',5'-Dichlorphenyl)-imidazol | 92706-34-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4(5)-(2',5'-Dichlorphenyl)-imidazol
• 英文别名: 5-(2,5-dichlorophenyl)-1H-imidazole
• CAS: 92706-34-8
• 化学式: C₉H₆Cl₂N₂
• 分子量: 213.066
• InChiKey: LCLUSPLHOKXHGN-UHFFFAOYSA-N

物化性质

• 沸点：
  408.3±30.0 °C(Predicted)
• 密度：
  1.418±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SUBSTITUTED AZOLE DERIVATIVES AS THERAPEUTIC AGENTS<br/>[FR] DERIVES D'AZOLE SUBSTITUES COMME AGENTS THERAPEUTIQUES
  申请人：TRANSTECH PHARMA INC

  公开号：WO2004071448A2

  公开（公告）日：2004-08-26

  This invention provides azoles which may be useful as inhibitors of protein tyrosine phosphatases (PTPases). The present invention provides compounds of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds and their use in treating human or animal disorders. The compounds of the invention may be useful as inhibitors of protein tyrosine phosphatases and thus can be useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes, Type II diabetes.