3-(1,3-dihydro-6-ethyl-4-hydroxy-7-methyl-3-oxoisobenzofuran-5-ylmethyl)-2-methylcyclopent-2-en-1-ylacetic acid | 1237770-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 3-(1,3-dihydro-6-ethyl-4-hydroxy-7-methyl-3-oxoisobenzofuran-5-ylmethyl)-2-methylcyclopent-2-en-1-ylacetic acid
• 英文别名: 2-[3-[(6-ethyl-4-hydroxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)methyl]-2-methylcyclopent-2-en-1-yl]acetic acid
• CAS: 1237770-95-4
• 化学式: C₂₀H₂₄O₅
• 分子量: 344.408
• InChiKey: UKWOJCOKEZGKRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Metabolism-modulating agents and uses therefor
  申请人：Whitehead Paul Jonathan

  公开号：US20060106097A1

  公开（公告）日：2006-05-18

  The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5′ monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
• US5444072A
  申请人：——

  公开号：US5444072A

  公开（公告）日：1995-08-22
• US5536747A
  申请人：——

  公开号：US5536747A

  公开（公告）日：1996-07-16
• US7915255B2
  申请人：——

  公开号：US7915255B2

  公开（公告）日：2011-03-29
• [EN] 6-SUBSTITUTED MYCOPHENOLIC AND DERIVATIVES WITH IMMUNOSUPPRESSIVE ACTIVITY<br/>[FR] DERIVES SUBSTITUES EN 6 DE L'ACIDE MYCOPHENOLIQUE A EFFET IMMUNOSUPPRESSEUR
  申请人：SYNTEX (U.S.A.) INC.

  公开号：WO1995022536A1

  公开（公告）日：1995-08-24

  (EN) The disclosed 6-substituted derivatives of mycophenolic acid of formula (I) are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.(FR) Dérivés substitués en 6 de l'acide mycophénolique de formule (I) servant d'agents thérapeutiques dans le traitement d'affections relevant de l'acide mycophénolique et/ou du mycophénolate de morpholinoéthyle.