3-Amino-5-(p-isopropyl-phenyl)-1,2,4-triazol | 20586-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Amino-5-(p-isopropyl-phenyl)-1,2,4-triazol
• 英文别名: 5-(4-isopropyl-phenyl)-1H-[1,2,4]triazol-3-ylamine；5-(4-propan-2-ylphenyl)-1H-1,2,4-triazol-3-amine
• CAS: 20586-96-3
• 化学式: C₁₁H₁₄N₄
• 分子量: 202.259
• InChiKey: TZLDNVUKHFRJDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• RHO KINASE INHIBITORS
  申请人：Cook Brian Nicholas

  公开号：US20120165322A1

  公开（公告）日：2012-06-28

  The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  本发明涉及式(I)的化合物和其药学上可接受的盐，其中R1和R2的定义如本文所述。本发明还涉及包含这些化合物的药物组合物、使用这些化合物治疗各种疾病和障碍的方法、制备这些化合物的过程以及在这些过程中有用的中间体。
• NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
  申请人：Cooper Alan B.

  公开号：US20110189192A1

  公开（公告）日：2011-08-04

  Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, and solvates thereof. Q is a tetrahydropyridinyl ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

  本发明公开了化学式1.0的ERK抑制剂，以及其药学上可接受的盐和溶剂化物。其中，Q代表四氢吡啶环。所有其他取代基的定义如本文所述。此外，本发明还公开了使用化合物1.0治疗癌症的方法。
• FUNCTIONAL FLUID
  申请人：Chiyoda Chemical Co. Ltd

  公开号：EP2159274A1

  公开（公告）日：2010-03-03

  Provided is a functional fluid including a tetrazole compound (A) and a base oil (B), which may further include a triazole compound (C).

  本发明提供了一种功能性流体，包括四唑化合物（A）和基础油（B），其中可进一步包括三唑化合物（C）。
• BRAKE FLUID CONTAINING TETRAZOLE
  申请人：Chiyoda Chemical Co. Ltd

  公开号：EP2159274B1

  公开（公告）日：2013-04-17
• FUNCTIONAL FLUID COMPOSITIONS
  申请人：Kukdong Jeyen Company Limited

  公开号：US20190161699A1

  公开（公告）日：2019-05-30

  The present invention relates to a functional fluid composition comprising a glycol as a base material and a diamine-based noise reducer. According to the present invention as such, the functional fluid composition comprising a glycol as a base material and a diamine-based noise reducer represented by chemical formula 1 has an excellent noise reducing effect. In addition, the functional fluid composition of the present invention has an excellent metal corrosion inhibiting effect even, by using a diamine-based compound as a noise reducer, when a metal corrosion inhibitor composed of a triazole-based compound without including an amine-based compound is used as a metal corrosion inhibitor.