4-(6,6-dimethyl-4-oxo-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide | 1073971-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(6,6-dimethyl-4-oxo-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide
• 英文别名: 4-[6,6-Dimethyl-4-oxo-3-(pyridin-2-ylmethyl)-5,7-dihydroindazol-1-yl]-2-(2-hydroxyethylamino)benzamide
• CAS: 1073971-25-1
• 化学式: C₂₄H₂₇N₅O₃
• 分子量: 433.51
• InChiKey: UQOMRKHLICTJLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Tetrahydroindole and Tetrahydroindazole Derivatives
  申请人：Huang Kenneth He

  公开号：US20080269193A1

  公开（公告）日：2008-10-30

  The invention provides indole and indazole compounds of Formula (I) or pharmaceutically acceptable salts thereof which are useful for treating and/or preventing diseases and/or disorders ameliorated by the inhibition of Heat-Shock Protein 90. The invention further provides pharmaceutical compositions comprising compounds of Formula (I) and methods of preparing compounds of Formula (I).

  该发明提供了式（I）的吲哚和吲唑化合物，或其药学上可接受的盐，用于治疗和/或预防通过抑制热休克蛋白90改善的疾病和/或紊乱。该发明还提供了包含式（I）化合物的药物组合物以及制备式（I）化合物的方法。
• TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES
  申请人：Serenex, Inc.

  公开号：EP2146967A2

  公开（公告）日：2010-01-27
• USE OF TETRAHYDROINDAZOLYLBENZAMIDE AND TETRAHYDROINDOLYLBENZAMIDE DERIVATIVES FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS)
  申请人：Esanex, Inc.

  公开号：US20160143884A1

  公开（公告）日：2016-05-26

  Provided are methods of treating or inhibiting Human Immunodeficiency Virus (HIV) infection, or treating or inhibiting Acquired Human Immunodeficiency Syndrome (AIDS) in a subject in need thereof, comprising administering an Hsp90 inhibitor in a therapeutically effective amount.
• [EN] TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE TÉTRAHYDROINDOLE ET DE TÉTRAHYDROINDAZOLE
  申请人：SERENEX INC

  公开号：WO2008130879A2

  公开（公告）日：2008-10-30

  [EN] The invention provides indole and indazole compounds of Formula (I) or pharmaceutically acceptable salts thereof which are useful for treating and/or preventing diseases and/or disorders ameliorated by the inhibition of Heat-Shock Protein 90. The invention further provides pharmaceutical compositions comprising compounds of Formula (I) and methods of preparing compounds of Formula (I).
  [FR] L'invention concerne des composés d'indole et d'indazole de formule (I) ou leurs sels pharmaceutiquement acceptables. Les composés selon l'invention sont utiles pour le traitement et/ou la prévention de maladies et/ou de troubles améliorés par l'inhibition de la protéine Hsp90 (Heat-Shock Protein 90). L'invention concerne également des compositions pharmaceutiques qui comprennent des composés de formule (I) et des procédés de préparation des composés de formule (I).