N-[(5S)-3-(3-fluoro-4-{3-[3-(4-trifluoromethyl-phenyl)-pyrazol-1-yl]pyrrolidin-1-yl}-phenyl)-2-oxo-5-oxazolidinylmethyl]acetamide | 1203468-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[(5S)-3-(3-fluoro-4-{3-[3-(4-trifluoromethyl-phenyl)-pyrazol-1-yl]pyrrolidin-1-yl}-phenyl)-2-oxo-5-oxazolidinylmethyl]acetamide
• 英文别名: N-[[(5S)-3-[3-fluoro-4-[3-[3-[4-(trifluoromethyl)phenyl]pyrazol-1-yl]pyrrolidin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• CAS: 1203468-23-8
• 化学式: C₂₆H₂₅F₄N₅O₃
• 分子量: 531.51
• InChiKey: UIJLZHOJUJLXRO-LBAQZLPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 3-(n-heterocyclyl)-pyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
  申请人：Ferrer Internacional, S.A.

  公开号：EP2141162A1

  公开（公告）日：2010-01-06

  The invention provides new oxazolidinone compounds of formula (I) wherein R, R1, R2 and R3 have different meanings. Preparative processes, pharmaceutical compositions, and uses thereof in the treatment of bacterial infections are also provided.

  该发明提供了新的氧唑啉酮化合物，其化学式为（I），其中R、R1、R2和R3具有不同的含义。还提供了制备方法、药物组合物以及在治疗细菌感染中的用途。
• 3-(N-HETEROCYCLYL)-PYRROLIDINYL-PHENYL-OXAZOLIDINONES AS ANTIBACTERIAL AGENTS
  申请人：Cano Montserrat

  公开号：US20110136829A1

  公开（公告）日：2011-06-09

  The invention provides new oxazolidinone compounds of formula (I) wherein R, R 1 , R 2 and R 3 have different meanings. Preparative processes, pharmaceutical compositions, and uses thereof in the treatment of bacterial infections are also provided.

  本发明提供了新的氧氮杂环丙酮类化合物，其化学式为(I)，其中R、R1、R2和R3具有不同的含义。还提供了制备过程、制药组合物以及在治疗细菌感染中的用途。
• [EN] 3-(N-HETEROCYCLYL)-PYRROLIDINYL-PHENYL-OXAZOLIDINONES AS ANTIBACTERIAL AGENTS<br/>[FR] 3-(N-HÉTÉROCYCLYL)-PYRROLIDINYL-PHÉNYL-OXAZOLIDINONES COMME AGENTS ANTIBACTÉRIENS
  申请人：FERRER INT

  公开号：WO2010000704A1

  公开（公告）日：2010-01-07

  The invention provides new oxazolidinone compounds of formula (I) wherein R, R1, R2 and R3 have different meanings. Preparative processes, pharmaceutical compositions, and uses thereof in the treatment of bacterial infections are also provided.