(2R,3S,2'S)-N-(3-tert-butyldimethylsilyl-5-methylhex-2-yl)-N-(2'-methoxymethylpyrrolidin-1'-yl)-trifluoroacetamide | 196931-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (2R,3S,2'S)-N-(3-tert-butyldimethylsilyl-5-methylhex-2-yl)-N-(2'-methoxymethylpyrrolidin-1'-yl)-trifluoroacetamide
• CAS: 196931-97-2
• 化学式: C₂₁H₄₁F₃N₂O₂Si
• 分子量: 438.649
• InChiKey: HPTSZBONADHHJC-SQNIBIBYSA-N

反应信息

• 作为反应物：
  描述：

  (2R,3S,2'S)-N-(3-tert-butyldimethylsilyl-5-methylhex-2-yl)-N-(2'-methoxymethylpyrrolidin-1'-yl)-trifluoroacetamide 在 氨 、 lithium 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 (1R,2S)-2-(tert-Butyl-dimethyl-silanyl)-1,4-dimethyl-pentylamine
  参考文献：
  名称：

  Diastereo- and enantioselective synthesis of protected vicinal silylamines via 1,2-addition to α-silyl-hydrazones

  摘要：

  Nucleophilic 1,2-addition of MeLi/CeCl3 to alpha-silylaldehyde-SAMP-hydrazones 2 and subsequent reductive NN bond cleavage affords protected vicinal silylamines 4 in good yields with high diastereomeric and enantiomeric excesses. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00321-2
• 作为产物：
  描述：

  甲基锂 、 三氟乙酸酐 、 [(S)-2-(tert-Butyl-dimethyl-silanyl)-4-methyl-pent-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 在 cerium(III) chloride 作用下， 生成 (2R,3S,2'S)-N-(3-tert-butyldimethylsilyl-5-methylhex-2-yl)-N-(2'-methoxymethylpyrrolidin-1'-yl)-trifluoroacetamide
  参考文献：
  名称：

  Diastereo- and enantioselective synthesis of protected vicinal silylamines via 1,2-addition to α-silyl-hydrazones

  摘要：

  Nucleophilic 1,2-addition of MeLi/CeCl3 to alpha-silylaldehyde-SAMP-hydrazones 2 and subsequent reductive NN bond cleavage affords protected vicinal silylamines 4 in good yields with high diastereomeric and enantiomeric excesses. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00321-2