(2-Amino-1,3-thiazol-4-YL)[(carboxymethoxy)imino]acetic acid | 74440-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2-Amino-1,3-thiazol-4-YL)[(carboxymethoxy)imino]acetic acid
• 英文别名: 2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetic acid
• CAS: 74440-05-4
• 化学式: C₇H₇N₃O₅S
• 分子量: 245.22
• InChiKey: BTBQXVJMMALOJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  163
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF CEFIXIME VIA ALKYL-OR ARYL-SULFONATES<br/>[FR] PROCEDE DE PREPARATION DE CEFIXIME VIA DES ALKYLSULFONATES OU ARYLSULFONATES
  申请人：ANTIBIOTICOS SPA

  公开号：WO2003040148A1

  公开（公告）日：2003-05-15

  A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).

  一种制备头孢克肟的方法，即通过烷基或芳基磺酸盐的通用公式（IA）制备7-[2-(2-氨基噻唑-4-基)-2-(羧甲氧亚氨基)乙酰氨基]-3-乙烯基-3-头孢烯-4-羧酸。
• [EN] NEW THIAZOL COMPOUNDS AND THEIR PREPARATIONS<br/>[FR] NOUVEAUX COMPOSES THIAZOLE ET PROCEDES DE PREPARATION ASSOCIES
  申请人：HANMI FINE CHEMICALS CO LTD

  公开号：WO2001066532A1

  公开（公告）日：2001-09-13

  The present invention relates to a new crystalline aminothiazole derivative represented by the following formula (I) which is very useful for the preparation of cephalosporin antibiotics, including ceftazidime and cefixime, etc: wherein R1 and R2 are the same or different and independently represent H, an alkyl group of 1 to 4 carbon atoms, or a cycloalkyl group of 3 to 5 carbon atoms, X represents chlorine or bromine, and the acid in the acid addition salt represents an inorganic acid, such as hydrochloric acid, hydrobromic acid, sulfuric acid, or perchloric acid, or an organic acid, such as formic acid, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, or benzenesulfonic acid.

  本发明涉及一种新的晶体氨基噻唑衍生物，其表示为以下公式（I），对头孢曲松、头孢噻唑等头孢菌素的制备非常有用：其中，R1和R2相同或不同，且独立地表示1至4个碳原子的烷基或3至5个碳原子的环烷基，X表示氯或溴，酸加成盐中的酸表示无机酸，例如盐酸、溴酸、硫酸或高氯酸，或有机酸，例如甲酸、乙酸、三氟乙酸、丙酸、甲磺酸或苯磺酸。
• Beta-lactam antibiotics
  申请人：ELI LILLY AND COMPANY

  公开号：EP0186463A2

  公开（公告）日：1986-07-02

  7β-[2-(2-Aminothiazol(oxazol)-4-yl)-2-oxomino-acetamido]-3-(substituted thiazolium-3-yl)methyl-3-cephem-4-carboxylates and the correspondingly substituted 1-oxadethia and 1-carbadethia 3-cephem compounds are potent antibacterials useful in a therapeutic method for treating bacterial diseases. Also provided are pharmaceutical formulations of these thiazolium-substituted compounds and intermediates useful in the preparation thereof.

  7β-[2-(2-氨基噻唑(恶唑)-4-基)-2-氧代氨基乙酰氨基]-3-(取代的噻唑鎓-3-基)甲基-3-头孢-4-羧酸盐和相应取代的 1-氧代头孢和 1-头孢-3-羧酸盐化合物是强效抗菌剂，可用于治疗细菌性疾病。此外，还提供了这些噻唑取代化合物的药物制剂及其制备中间体。
• Process for the preparation of cefixime via alkyl-or aryl-sulfonates
  申请人：Cabri Walter

  公开号：US20050032771A1

  公开（公告）日：2005-02-10

  A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).

  一种通过通式（IA）的烷基或芳基磺酸盐制备头孢克肟，即 7-[2-(2-氨基噻唑-4-基)-2-(羧甲氧亚氨基)乙酰氨基]-3-乙烯基-3-头孢-4-羧酸的工艺。
• NEW THIAZOL COMPOUNDS AND THEIR PREPARATIONS
  申请人：Hanmi Fine Chemicals Co., Ltd.

  公开号：EP1274695B1

  公开（公告）日：2011-01-12