3-(5-chlorooxazolo[5,4-b]pyridine-2-yl)benzonitrile | 1125871-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(5-chlorooxazolo[5,4-b]pyridine-2-yl)benzonitrile
• 英文别名: 3-(5-chloro-oxazolo[5,4-b]pyridin-2-yl)-benzonitrile；3-(5-chloro-[1,3]oxazolo[5,4-b]pyridin-2-yl)benzonitrile
• CAS: 1125871-70-6
• 化学式: C₁₃H₆ClN₃O
• 分子量: 255.663
• InChiKey: DLCVGLSJNKLDKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 5-6-BICYCLIC HETEROAROMATIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY<br/>[FR] COMPOSÉS HÉTÉROAROMATIQUES 5-6-BICYCLIQUES POSSÉDANT UNE ACTIVITÉ ANTIBACTÉRIENNE
  申请人：ASTRAZENECA AB

  公开号：WO2009027732A1

  公开（公告）日：2009-03-05

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  描述了化学式（I）的化合物及其药用盐。还描述了它们的制备过程、含有它们的药物组合物、它们作为药物的用途以及它们在治疗细菌感染中的用途。
• PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME
  申请人：LEE Changjoon Justin

  公开号：US20130046093A1

  公开（公告）日：2013-02-21

  A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.

  一种用于预防或治疗退行性脑疾病的药物组合物，以及一种筛选预防或治疗退行性脑疾病材料的方法。该方法可以有效地筛选预防或治疗退行性脑疾病的预防性或治疗性候选材料。使用该药物组合物，包括筛选用于预防或治疗退行性脑疾病的材料，可以有效预防或治疗各种退行性脑疾病。
• Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
  申请人：Korea Institute of Science and Technology

  公开号：EP2560008A2

  公开（公告）日：2013-02-20

  A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.

  一种用于预防或治疗退行性脑病的药物组合物，以及一种用于预防或治疗退行性脑病的材料筛选方法。 该方法可有效筛选出预防或治疗变性脑病的候选材料。 使用包括经筛选的用于预防或治疗退行性脑病的材料的药物组合物，可有效预防或治疗各种退行性脑病。
• US9469653B2
  申请人：——

  公开号：US9469653B2

  公开（公告）日：2016-10-18