(2-Methyl-2H-pyrazol-3-yl)acrylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2-Methyl-2H-pyrazol-3-yl)acrylic acid
• 英文别名: 3-(2-methylpyrazol-3-yl)prop-2-enoic acid
• 化学式: C₇H₈N₂O₂
• mdl: MFCD08559038
• 分子量: 152.15
• InChiKey: FLMCGVRZSZMFDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• ANTI-HIV COMPOUNDS
  申请人：Prosetta Antiviral, Inc.

  公开号：US20160168100A1

  公开（公告）日：2016-06-16

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.

  这项发明提供了用于治疗病毒感染的四氢异喹啉等化合物，含有这类化合物的药物配方，以及抑制病毒（如HIV）复制或治疗疾病（如艾滋病）的方法。
• [EN] CEPHEM COMPOUNDS<br/>[FR] COMPOSES CEPHEMES
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004101571A1

  公开（公告）日：2004-11-25

  The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl which may have suitable substituent(s), R2 is amino, protected amino or guanidino, R3 is carboxy or protected carboxy, R4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

  本发明涉及一种化合物，其化学式为[I]：其中R1是可能具有适当取代基的低碳烷基，R2是氨基、保护氨基或胍基，R3是羧基或保护羧基，R4是氨基或保护氨基，A是低碳烷基，或其在药学上可接受的盐，一种制备化合物[I]的方法，以及包含化合物[I]与药学上可接受的载体混合的药物组合物。
• Cephem compounds
  申请人：Yamanaka Toshio

  公开号：US20050004094A1

  公开（公告）日：2005-01-06

  The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl which may have suitable substituent(s), R 2 is amino, protected amino or guanidino, R 3 is carboxy or protected carboxy, R 4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

  本发明涉及一种化合物，其化学式为[I]，其中R1是较低的烷基，可以具有适当的取代基；R2是氨基，保护氨基或鸟氨酸基；R3是羧基或保护羧基；R4是氨基或保护氨基，A是较低的烷基烯，或其药学上可接受的盐，以及制备化合物[I]的方法和包含化合物[I]的药物组合物与药学上可接受的载体混合的药物组合物。
• 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds
  申请人：Prosetta Antiviral, Inc.

  公开号：US10195189B2

  公开（公告）日：2019-02-05

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.

  除其他外，本发明还提供了用于治疗病毒感染的四氢异喹啉类化合物、含有此类化合物的药物制剂，以及抑制艾滋病毒等病毒复制或治疗艾滋病等疾病的方法。
• 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS
  申请人：Prosetta Antiviral, Inc.

  公开号：US20170368051A1

  公开（公告）日：2017-12-28

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.