5-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester | 220069-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 5-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester
• CAS: 220069-69-2
• 化学式: C₁₃H₁₀ClNO₄
• 分子量: 279.68
• InChiKey: NJEUVBCICMOTKL-TWGQIWQCSA-N

反应信息

• 作为反应物：
  描述：

  5-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 在 rhodium(II) acetate dimer 对甲苯磺酰叠氮 、 水 、 三乙胺 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 4.17h， 生成 5-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-4-hydroxy-3-(4-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one
  参考文献：
  名称：

  5-Arylidene-3-aryl-pyrrolidine-2,4-diones with Affinity to theN-Methyl-D-aspartate (Glycine Site) Receptor, Part I

  摘要：

  A series of new 5-arylidene 3-aryl-pyrrolidine-2,4-diones has been prepared. Their binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more derailed structure-activity relationship studies.

  DOI：

  10.1002/(sici)1521-4184(199812)331:12<389::aid-ardp389>3.0.co;2-w
• 作为产物：
  描述：

  1-Benzoyl-5-[1-(3-chloro-phenyl)-meth-(Z)-ylidene]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 5-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester
  参考文献：
  名称：

  5-Arylidene-3-aryl-pyrrolidine-2,4-diones with Affinity to theN-Methyl-D-aspartate (Glycine Site) Receptor, Part I

  摘要：

  A series of new 5-arylidene 3-aryl-pyrrolidine-2,4-diones has been prepared. Their binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more derailed structure-activity relationship studies.

  DOI：

  10.1002/(sici)1521-4184(199812)331:12<389::aid-ardp389>3.0.co;2-w